CLONED FRAGMENTS OF THE PLASMID COLV,I-K94 SPECIFYING VIRULENCE AND SERUM RESISTANCE
CLONED FRAGMENTS OF THE PLASMID COLV,I-K94 SPECIFYING VIRULENCE AND SERUM RESISTANCE
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DOI：
10.1038/279778a0
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发表时间：
1979-01-01
期刊：
影响因子：
64.8
通讯作者：
HARDY, KG
中科院分区：
文献类型：
--
作者：
BINNS, MM;DAVIES, DL;HARDY, KG
克隆的BamH 1产生的ColV片段，I-K94增加了大肠杆菌的毒力，导致雏鸡的LD 50降低约100倍。血清杀菌作用抗性的遗传决定因素被映射到片段内的5300个碱基对序列。大肠杆菌素V和对大肠杆菌素V的免疫均不影响E.鸡的大肠杆菌。
A cloned BamH1-generated fragment of ColV,I-K94 increased the virulence of Escherichia coli, causing an approximately 100-fold reduction in LD50 for chicks. A genetic determinant for resistance to the bactericidal effects of serum was mapped to a 5300 base-pair sequence within the fragment. Neither colicin V nor immunity to colicin V affected the pathogenicity of E. coli for chicks.