Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel
Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel
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DOI：
10.1371/journal.pone.0216679
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发表时间：
2019-06-18
期刊：
影响因子：
3.7
通讯作者：
Hindmarch, Charles C. T.
中科院分区：
文献类型：
--
作者：
Alim, Fatma Zohra Djazouli;Romanova, Elena V.;Hindmarch, Charles C. T.
单峰骆驼是阿拉伯和北非沙漠的“船”，单峰骆驼（Camelus dromedarius）具有在极端炎热的条件下生存而无需喝水的非凡能力。实现这一目标的方法之一是通过抗利尿激素精氨酸加压素（AVP）的作用，AVP是在大脑的一个专门部分中产生的，称为下丘脑-神经垂体系统（HNS），但在肾脏水平发挥其作用，以促进水的保护。有趣的是，我们的电子显微镜研究表明，根据季节的单峰骆驼HNS的超微结构的变化，这表明在夏季的干旱条件下的HNS是在一个激活状态，在准备可能的前景缺水。基于我们的单峰骆驼基因组序列，我们对夏季和冬季的单峰骆驼HNS进行了RNAseq分析。在171个转录物中发现显著差异调节（>2倍变化，p值
The "ship" of the Arabian and North African deserts, the one-humped dromedary camel (Camelus dromedarius) has a remarkable capacity to survive in conditions of extreme heat without needing to drink water. One of the ways that this is achieved is through the actions of the antidiuretic hormone arginine vasopressin (AVP), which is made in a specialised part of the brain called the hypothalamo-neurohypophyseal system (HNS), but exerts its effects at the level of the kidney to provoke water conservation. Interestingly, our electron microscopy studies have shown that the ultrastructure of the dromedary HNS changes according to season, suggesting that in the arid conditions of summer the HNS is in an activated state, in preparation for the likely prospect of water deprivation. Based on our dromedary genome sequence, we have carried out an RNAseq analysis of the dromedary HNS in summer and winter. Amongst the 171 transcripts found to be significantly differentially regulated (>2 fold change, p value