Linkage-disequilibrium of the senegal haplotype with the beta S gene in the republic of guinea.
Linkage-disequilibrium of the senegal haplotype with the beta S gene in the republic of guinea.
复制标题
塞内加尔单倍型与几内亚共和国β S 基因的连锁不平衡。
DOI：
10.1002/ajh.2830500415
复制
发表时间：
1995
影响因子：
12.8
通讯作者：
Nagel,RL
中科院分区：
文献类型：
--
作者：
Sow,A;Peterson,E;Josifovska,O;Fabry,ME;Krishnamoorthy,R;Nagel,RL
我们已经确定了40条染色体上的β基因簇单倍型，这些染色体带有居住在几内亚共和国的主要民族个体的β突变体。其中31个是典型的塞内加尔单倍型(n=29)或非典型的塞内加尔单倍型(n=2)，表明在这个大西洋西非地区，镰状突变与这种特殊的β基因簇单倍型连锁不平衡。两名携带一条带有贝宁单倍型的染色体的人是马林克族人。这与塞内加尔β基因簇单倍型与西非大西洋地区的βSGENE有关的假设是一致的。
We have determined the β gene cluster haplotype in 40 chromosomes carrying the βsmutation from individuals of the major ethnic groups living in the Republic of Guinea. Thirty‐one of these were either the typical (n = 29) or the atypical (n = 2) Senegal haplotype demonstrating that in this region of Atlantic West Africa, the sickle mutation is in linkage disequilibrium with this particular β‐gene cluster haplotype. Two individuals carrying one chromosome bearing the Benin haplotype were of Malinke ethnic origin. This is in keeping with the hypothesis that the Senegal β‐gene cluster haplotype is linked to the βsgene in Atlantic West Africa.