NT Pro BNP Plasma Level and Atrial Volume Are Linked to the Severity of Liver Cirrhosis
NT Pro BNP Plasma Level and Atrial Volume Are Linked to the Severity of Liver Cirrhosis
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DOI：
10.1371/journal.pone.0068364
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发表时间：
2013-08-05
期刊：
影响因子：
3.7
通讯作者：
Craxi, Antonio
中科院分区：
文献类型：
--
作者：
Licata, Anna;Corrao, Salvatore;Craxi, Antonio
背景和目标：血浆NT-pro-BNP（一种利钠肽前体）水平在存在心源性液体潴留时升高，可用作心功能障碍的标志物。最近的研究表明，肝硬化患者的NT proBNP水平较高。我们评估了NT pro-BNP和其他参数的心功能不全的肝硬化患者，有或无腹水，以确定是否NT pro-BNP的行为是链接到肝脏疾病的阶段或继发性cardiac dysfunction.Methods：58个连续住院患者大多与病毒性或NAFLD相关的肝硬化进行了研究。所有患者均接受腹部超声和上消化道内镜检查。通过超声心动图和入院时测定的NT-pro-BNP血浆水平评估心脏形态功能变化。28例高血压患者，没有证据的肝脏疾病作为controls.Results：58例糖尿病患者（72%男性），中位年龄为62岁（11%轻度动脉高血压和31% 2型糖尿病）有一个正常的肾功能（平均肌酐0.9毫克/分升，范围0.7-1.06）。与对照组相比，冠心病患者的NT pro-BNP血浆水平更高（365.2 +/- 365.2 vs 70.8 +/- 70.6 pg/ml; p
Background and Aims: Plasma levels of NT-pro-BNP, a natriuretic peptide precursor, are raised in the presence of fluid retention of cardiac origin and can be used as markers of cardiac dysfunction. Recent studies showed high levels of NT pro BNP in patients with cirrhosis. We assessed NT pro-BNP and other parameters of cardiac dysfunction in patients with cirrhosis, with or without ascites, in order to determine whether the behaviour of NT pro BNP is linked to the stage of liver disease or to secondary cardiac dysfunction.Methods: Fifty eight consecutive hospitalized patients mostly with viral or NAFLD-related cirrhosis were studied. All underwent abdominal ultrasound and upper GI endoscopy. Cardiac morpho-functional changes were evaluated by echocardiography and NT-pro-BNP plasma levels determined upon admission. Twenty-eight hypertensive patients, without evidence of liver disease served as controls.Results: Fifty eight cirrhotic patients (72% men) with a median age of 62 years (11% with mild arterial hypertension and 31% with type 2 diabetes) had a normal renal function (mean creatinine 0.9 mg/dl, range 0.7-1.06). As compared to controls, cirrhotic patients had higher NT pro-BNP plasma levels (365.2 +/- 365.2 vs 70.8 +/- 70.6 pg/ml; p