Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states
Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states
复制标题
DOI：
10.7554/elife.53125
复制
发表时间：
2020-07-14
期刊：
影响因子：
7.7
通讯作者：
Franks, Kevin M.
中科院分区：
文献类型：
--
作者：
Bolding, Kevin A.;Nagappan, Shivathmihai;Franks, Kevin M.
模式完成，或从嘈杂或部分线索中恢复稳定的神经活动模式的能力，是记忆的一个基本特征。理论研究表明，循环连接的自联想或离散吸引子网络可以执行这一过程。虽然模式完成和吸引子动力学已经在各种递归神经回路中观察到，但递归回路在实现这些过程中所起的作用仍然不清楚。在头部固定的小鼠的记录中，我们发现在氯胺酮/甲苯噻嗪麻醉下嗅球中的气味反应降低，而在梨状皮质中的下游反应保持稳健。需要经常性的连接来稳定不同状态的皮质气味表征。此外，梨状气味表征表现出吸引动力学，无论是内部和跨试验，这些也被废除时，经常性的电路被消除。在这里，我们提出了收敛的证据表明，经常性连接的梨状种群稳定的感觉表征，响应于退化的输入，与梨状皮质的自联想功能支持的经常性电路一致。
Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion and attractor dynamics have been observed in various recurrent neural circuits, the role recurrent circuitry plays in implementing these processes remains unclear. In recordings from head-fixed mice, we found that odor responses in olfactory bulb degrade under ketamine/xylazine anesthesia while responses immediately downstream, in piriform cortex, remain robust. Recurrent connections are required to stabilize cortical odor representations across states. Moreover, piriform odor representations exhibit attractor dynamics, both within and across trials, and these are also abolished when recurrent circuitry is eliminated. Here, we present converging evidence that recurrently-connected piriform populations stabilize sensory representations in response to degraded inputs, consistent with an auto-associative function for piriform cortex supported by recurrent circuitry.