Mechanism of Diapedesis: Importance of the Transcellular Route.
Mechanism of Diapedesis: Importance of the Transcellular Route.
复制标题
DOI：
10.1016/bs.ai.2015.09.001
复制
发表时间：
2016
影响因子：
--
通讯作者：
Filippi MD
中科院分区：
文献类型：
--
作者：
Filippi MD
中性粒细胞通过血液内皮细胞屏障的迁移是先天炎症的先决条件。中性粒细胞重新聚集到炎症组织中是以一种明确的循序渐进的方式发生的，其中包括中性粒细胞滚动、牢固的黏附和爬行到内皮细胞表面，然后反式迁移穿过内皮屏障。后一步被称为汇合，可以发生在内皮细胞交界处(细胞旁)，也可以直接通过内皮细胞体(跨细胞)。外渗级联受各种黏附模块的一系列接触控制，这些黏附模块导致中性粒细胞和内皮细胞的双向信号被激活，以获得足够的细胞反应。本文将重点介绍白细胞爬行和穿透机制的最新研究进展，重点介绍白细胞与内皮细胞的相互作用及其信号转导途径，以确定穿透的方式，即连接或非连接。我还将讨论新出现的证据，强调这两种模式的关键差异，以及为什么在临床上了解专一性在调节汇合中的重要性。
The neutrophil transmigration across the blood endothelial cell barrier represents the prerequisite step of innate inflammation. Neutrophil recruitment to inflamed tissues occurs in a well-defined stepwise manner, which includes elements of neutrophil rolling, firm adhesion, and crawling onto the endothelial cell surface before trans-migrating across the endothelial barrier. This latter step known as diapedesis can occur at the endothelial cell junction (paracellular) or directly through the endothelial cell body (transcellular). The extravasation cascade is controlled by series of engagement of various adhesive modules, which result in activation of bidirectional signals to neutrophils and endothelial cells for adequate cellular response. This review will focus on recent advances in our understanding of mechanism of leukocyte crawling and diapedesis, with an emphasis on leukocyte–endothelial interactions and the signaling pathways they transduce to determine the mode of diapedesis, junctional or non-junctional. I will also discuss emerging evidence highlighting key differences in the two modes of diapedesis and why it is clinically important to understand specificity in the regulation of diapedesis.