Microbiome-Gut-Brain Axis as a Biomolecular Communication Network for the Internet of Bio-NanoThings
Microbiome-Gut-Brain Axis as a Biomolecular Communication Network for the Internet of Bio-NanoThings
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DOI：
10.1109/access.2019.2942312
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发表时间：
2019-01-01
期刊：
影响因子：
3.9
通讯作者：
Unluturk, Bige D.
中科院分区：
文献类型：
--
作者：
Akyildiz, Ian F.;Chen, Jiande;Unluturk, Bige D.
本文介绍了在开发自我可持续和生物兼容的网络基础设施以互连下一代电气和生物可穿戴和可植入设备，即生物纳米事物互联网方面面临的根本挑战。IoBNT设备与人体的直接接触，细胞在其中自然通信并组织成网络，这表明有可能利用这些生物通信来实现设备到设备的互连。这项工作的目的是研究微创、异质和外部可访问的电子/分子通信渠道，以通过由肠道微生物群落、肠道组织和肠道神经系统组成的微生物组-肠道-脑轴(MGBA)在这些设备之间传输信息。提出了一个框架，用于在MGBA的生物过程及其组件之间的相互通信的基础上开发网络基础设施。要实施这一框架，需要解决以下挑战。首先，应该开发物理通道模型，以定量描述通过MGBA进行的电子和分子通信。第二，在信息调制、编码和路由方面开发新的技术解决方案。第三，为了用实验数据支持这些努力，应该设计和设计一种第一种可植入的MGBA网络探头设备，该设备由连接到电子和分子刺激和传感模块的集线器组成，以及创新的芯片上肠道体外模型系统。本文的讨论为一个全新的跨学科网络领域奠定了基础，该网络领域是用于普及、永久和远程医疗的下一代生物医学系统的核心。
This article presents fundamental challenges in the development of a self-sustainable and biocompatible network infrastructure to interconnect the next-generation electrical and biological wearable and implantable devices, i.e., the Internet of Bio-NanoThings. The direct contact of IoBNT devices with the human body, where the cells naturally communicate and organize into networks, suggests the possibility to exploit these biological communications for the device-to-device interconnection. The aim of this work is to investigate minimally invasive, heterogeneous, and externally accessible electrical/molecular communication channels to transmit information between these devices through the Microbiome-Gut-Brain Axis (MGBA), composed of the gut microbial community, the gut tissues, the enteric nervous system. A framework to develop a network infrastructure on top of the biological processes underlying the MGBA, and the intercommunications among its components is proposed. To implement this framework, the following challenges need to be tackled. First, physical channel models should be developed to quantitatively characterize electrical and molecular communications through the MGBA. Second, novel technological solutions in information modulation, coding and routing should be developed. Third, to support these efforts with experimental data, a first-of-a-kind implantable MGBA network probe device composed of a hub connected to an ensemble of electrical and molecular stimulation and sensing modules should be designed and engineered, together with an innovative gut-on-a-chip in-vitro model system. The discussion in this paper establishes the basis for a completely novel transdisciplinary networking domain at the core of the next-generation biomedical systems for pervasive, perpetual, and remote healthcare.