Temporal matching of sensory-motor behavior and limbic theta rhythm deteriorates in aging rats.
Temporal matching of sensory-motor behavior and limbic theta rhythm deteriorates in aging rats.
复制标题
老年大鼠的感觉运动行为和边缘θ节律的时间匹配恶化。
DOI：
10.1016/0197-4580(84)90080-0
复制
发表时间：
1984
影响因子：
4.2
通讯作者：
Macrides,F
中科院分区：
文献类型：
--
作者：
Forbes,WB;Macrides,F
The correlations between ivestigatory sniffing and rhythmic slow-wave activity (RSA) in the dorsal hippocampal formation were studied during free behavior in Fischer 344 rats aged 3, 18, 30, and 36 months. The amount and vigor of spontaneous exploratory behavior was reduced in older animals, and the frequency distributions of investigatory sniffing and hippocampal RSA both shifted with age toward the lower end of their normal ranges. In the youngest animals, (1) the dominant frequency of sniffing matched that of hippocampal RSA (freequency entrainment) more often than would be predicted by enhance; (2) preferred preffered phase differences between sniffing and hippocampal RSA were reliability observed in the 5–9 Hz range; and (3) these preferred phase differences varied linearly as a function of frequency, implying an underlying latency relationship. These correlations changed progressively with age as follows: (1) the incidence of frequency entrainments decreased; (2) the frequency range within which preffered phase differences were observed became lower and narrower; and (3) the incidence of preferred phase differences decreased. However, animals of all ages exhibited similar preferred phase differences for those frequencies at which significant preferences were expressed. These findings are discussed in relation to the hypothesis that alterations of forebrain θ rhythms may accompany aberrations of the medial septum-diagonal band-nucleus basalis complex and may be importantly involved in aging-related impairments of cognitive and learning abilities.
