Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands
Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands
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DOI：
10.1186/1471-2350-10-107
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发表时间：
2009-10-23
影响因子：
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通讯作者：
McGarvey, Stephen T.
中科院分区：
文献类型：
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作者：
Aberg, Karolina;Dai, Feng;McGarvey, Stephen T.
背景：高血压或高血压是心血管疾病发生的主要危险因素。我们进行了全基因组方差成分连锁分析，以寻找影响五种血压相关性状的基因座，包括居住在美属萨摩亚和萨摩亚的家庭以及两个政体的组合样本中的收缩压（SBP）、舒张压（DBP）和脉压（PP）数量性状、二分性状高血压（HT）和双变量SBP-DBP。我们调整了许多环境协变量的特征，如吸烟、饮酒、体力活动和物质生活方式。结果：我们发现染色体 2q35-q37 上的 SBP (LOD 2.4) 和染色体 22q13 (LOD 2.2) 上的 PP 存在提示性单变量关联，这两个染色体区域最近分别与 SBP 和 PP 相关。结论：我们发现了最近报告的基因座相关的更多证据2q 染色体上有 SBP，22q 染色体上有 PP 易感位点。然而，我们来自萨摩亚群岛的三个部分重叠的遗传同质研究样本的结果之间观察到的差异表明，应该进行额外的研究以验证这些结果。
Background: High blood pressure or hypertension is a major risk factor involved in the development of cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing five blood pressure related traits including the quantitative traits systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP), the dichotomous trait hypertension (HT) and the bivariate quantitative trait SBP-DBP in families residing in American Samoa and Samoa, as well as in the combined sample from the two polities. We adjusted the traits for a number of environmental covariates such as smoking, alcohol consumption, physical activity and material life style.Results: We found suggestive univariate linkage for SBP on chromosome 2q35-q37 (LOD 2.4) and for PP on chromosome 22q13 (LOD 2.2), two chromosomal regions that recently have been associated with SBP and PP, respectively.Conclusion: We have detected additional evidence for a recently reported locus associated with SBP on chromosome 2q and a susceptibility locus for PP on chromosome 22q. However, differences observed between the results from our three partly overlapping genetically homogenous study samples from the Samoan islands suggest that additional studies should be performed in order to verify these results.