Presence and acquired origin of reduced recall for fear extinction in PTSD: Results of a twin study
Presence and acquired origin of reduced recall for fear extinction in PTSD: Results of a twin study
复制标题
DOI：
10.1016/j.jpsychires.2008.01.017
复制
发表时间：
2008-06-01
影响因子：
4.8
通讯作者：
Pitman, Roger K.
中科院分区：
文献类型：
--
作者：
Milad, Mohammed R.;Orr, Scott P.;Pitman, Roger K.
恐惧消退的回忆被认为有助于从心理创伤事件中恢复，被假设为创伤后应激障碍（PTSD）的缺陷，但这尚未在实验室中得到证实，也没有调查其起源。为了解决这两个问题，14对单卵双胞胎不一致的战斗暴露，其中7战斗暴露双胞胎有创伤后应激障碍，经历了为期两天的恐惧条件反射和灭绝程序。在第1天，受试者观看彩色光条件刺激，其中一些与轻度电击配对，随后条件反应消失。在第2天，回忆第1天的消退学习（即，消光保留）进行评估。皮肤电传导反应（SCR）是依赖性测量。在获得或消退学习过程中没有组间差异。然而，在灭绝回忆期间出现了显着的创伤后应激障碍诊断（在暴露的双胞胎中）x战斗暴露相互作用，创伤后应激障碍退伍军人的SCR比他们自己的同卵双胞胎更大，也比非创伤后应激障碍退伍军人及其同卵双胞胎更大。这些结果表明，创伤后应激障碍（PTSD）中条件性恐惧消退的保留是不足的。此外，他们支持这样的结论，即这种缺陷是由于战斗创伤导致PTSD而获得的，而不是在战斗压力下发展PTSD的诱发因素。(C)2008爱思唯尔有限公司保留所有权利。
Recall of fear extinction, which is thought to aid in recovery from a psychologically traumatic event, is hypothesized to be deficient in post-traumatic stress disorder (PTSD), but this has not yet been demonstrated in the laboratory, nor has its origin been investigated. To address these two issues, 14 pairs of monozygotic twins discordant for combat exposure, in 7 of which the combat-exposed twin had PTSD, underwent a two-day fear conditioning and extinction procedure. On Day 1, subjects viewed colored light conditioned stimuli, some of which were paired with mild electric shock, followed by extinction of the conditioned responses. On Day 2, recall of Day I extinction learning (i.e., extinction retention) was assessed. Skin conductance response (SCR) was the dependent measure. There were no group differences during acquisition or extinction learning. However, a significant PTSD Diagnosis (in the exposed twin) x combat Exposure interaction emerged during extinction recall, with the PTSD combat veterans having larger SCRs than their own co-twins, and than the non-PTSD combat veterans and their co-twins. These results indicate that retention of extinction of conditioned fear is deficient in PTSD. Furthermore, they support the conclusion that this deficit is acquired as a result of combat trauma leading to PTSD, rather than being a predisposing factor to developing PTSD upon the stress of combat. (C) 2008 Elsevier Ltd. All rights reserved.