Serum interleukin-8 levels are elevated in patients with ovarian endometrioma
Serum interleukin-8 levels are elevated in patients with ovarian endometrioma
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DOI：
10.1016/j.fertnstert.2007.07.1355
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发表时间：
2008-10-01
影响因子：
6.7
通讯作者：
Terakawa, Naoki
中科院分区：
文献类型：
--
作者：
Ohata, Yorie;Harada, Tasuku;Terakawa, Naoki
目标：为了确定是否可以测量卵巢恶性肿瘤患者的血清白细胞介素（IL）-8浓度，以及这种测量是否是诊断这种疾病的有用工具。设计：一项对照临床研究和一项体外研究。设置：日本鸟取大学妇产科。患者：70例卵巢恶性肿瘤患者和21例良性卵巢囊肿患者。干预：对卵巢恶性肿瘤或良性卵巢囊肿行腹腔镜手术或开腹手术。采集术前血液样本。结果：子宫内膜异位症患者血清IL-8浓度明显高于卵巢良性囊肿患者，卵巢良性囊肿患者血清IL-8浓度明显高于卵巢良性囊肿患者血清IL-8浓度，卵巢良性囊肿患者血清IL-8浓度明显高于卵巢良性囊肿患者血清IL-8浓度。血清IL-8阈值（25 pg/mL）诊断卵巢恶性肿瘤的敏感性（71.4%）高于血清CA-125。血清IL-8水平为25 pg/mL的患者加入TNF-α后培养上清中IL-8浓度的升高率显著高于血清IL-8水平为25 pg/mL的患者
Objective: To determine whether serum interleukin (IL)-8 concentration can be measured in patients with ovarian endometrioma and whether this measurement is a useful tool,in diagnosing this disease.Design: A controlled clinical study and an in vitro study.Setting: Department of Obstetrics and Gynecology, Tottori University, Japan.Patient(s): Seventy patients with ovarian endometrioma and 21 patients with benign ovarian cyst.Intervention(s): Laparoscopic surgery or laparotomy for ovarian endometriomas or benign ovarian cyst was performed. Preoperative blood samples were obtained. Endometriotic stromal cells obtained from nine patients with endometrioma were cultured.Main Outcome Measure(s): Interleukin-8 concentration in the serum or supernatant of the cell culture was measured with use of ELISA.Result(s): The serum concentration of IL-8 inpatients with endometrioma was significantly higher than inpatients with benign ovarian cyst. The serum IL-8 threshold (25 pg/mL) had a higher sensitivity (71.4%) for diagnosing ovarian endometrioma than did serum CA-125 level. The increased rates of IL-8 concentration in the culture supernatants after adding tumor necrosis factor a were significantly higher in patients whose serum IL-8 levels were 25 pg/mL than in those with levels