The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord.
The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord.
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DOI：
10.1016/0014-2999(92)90490-u
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发表时间：
1992-09
影响因子：
5
通讯作者：
Y. Takano;M. Takano;T. Yaksh
中科院分区：
文献类型：
--
作者：
Y. Takano;M. Takano;T. Yaksh
为明确WB4101(2-(2，6-dimethoxyphenoxyethyl)-aminomethyl-1，4-benzodioxane)和咪唑啉拮抗α2受体激动剂的脊髓抗伤害性反应的药理作用，观察了WB4101和咪唑啉拮抗ST-91(2-[2，6-二乙基苯氨基]-2-咪唑啉)、可乐定和右美托咪啶的作用。WB4101和咪唑安定可拮抗ST-91的抗伤害性作用，WB4101仅拮抗可乐定，两种拮抗剂均不拮抗右旋美托咪定。推测α-2肾上腺素受体亚型α-2A参与脊髓可乐定和右美托咪定的抗伤害作用，α-2B参与ST-91的抗伤害作用。
To define the antagonist pharmacology of spinal antinociceptive effect ofα2-adrenoceptor agonists, the ability of WB4101 (2-(2,6-dimethoxyphenoxyethyl)-aminomethyl-1,4-benzodioxane) and imiloxan to antagonize the effect of spinal ST-91 (2-[2,6-diethylphenylamino]-2- imidazoline), clonidine and dexmedetomidine was examined. Antinociceptive effects of ST-91 were antagonized by WB4101 and imiloxan; clonidine only by WB4101; and, dexmedetomidine was not antagonized by either antagonist. It is hypothesized that theα2adrenoceptor subtypeα2Ainvolved in the antinociception of spinal clonidine and dexmedetomidine, andα2Bis involved in that of ST-91.