Hyoscine butylbromide significantly decreases motion artefacts and allows better delineation of anatomic structures in mp-MRI of the prostate
Hyoscine butylbromide significantly decreases motion artefacts and allows better delineation of anatomic structures in mp-MRI of the prostate
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DOI：
10.1007/s00330-017-4940-7
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发表时间：
2018-01-01
影响因子：
5.9
通讯作者：
Schimmoeller, L.
中科院分区：
文献类型：
--
作者：
Ullrich, T.;Quentin, M.;Schimmoeller, L.
为了前瞻性评价丁溴东莨菪碱（HBB）对3.0特斯拉下前列腺mp-MRI中解剖细节和运动相关伪影可视化的影响，本试验纳入了103例连续患者（65 +/- 10岁），有把握证明HBB给药后图像质量的改善，由两名设盲的阅片员在5分量表上进行评估。所有患者均在3.0 T下接受高空间分辨率轴向T2加权TSE序列，无痉挛剂，在应用40 mg HBB后重复，随后进行常规mp-MRI。次要终点是（1）对副作用的敏感性，（2）痉挛效应对患者A体重的依赖性，和（3）前列腺体积。在68%的患者中，HBB显著改善了解剖学评分（对于两个读片者，HBB前和HBB后的平均值分别为3.4 ± 0.9和4.4 ± 0.7，p = < 0.001）。在67%的患者中，HBB显著增加了伪影评分（对于读片者1，HBB前平均3.2 +/- 1，读片者2，HBB后平均4.2 +/- 0.8，p = < 0.001;读片者2，HBB前平均3.2 +/- 1，读片者2，HBB后平均4.1 +/- 0.8，p = < 0.001）。亚组分析显示，不同体重或前列腺体积的患者之间无统计学显著差异。阅片者之间的一致性非常好（k = 0.95-0.98）。丁溴东莨菪碱显著改善了前列腺mp-MRI的图像质量，并减少了与体重或前列腺体积无关的运动相关伪影。没有报道副作用。a百分之一的丁溴东莨菪碱（HBB）改善了超过2/3的患者的图像质量。a百分之一的严重伪影在HBB后减少了超过20%。a百分之一的非诊断性MRI的数量在HBB后减少到< 1%。a百分之一的HBB影响与体重和前列腺体积无关。a百分之一的HBB在本研究人群中没有报道副作用。
To prospectively evaluate the effect of hyoscine butylbromide (HBB) on visualisation of anatomical details and motion-related artefacts in mp-MRI of the prostate at 3.0 Tesla.One hundred and three consecutive patients (65 +/- 10 years) were included in this trial, powered to demonstrate an improvement of image quality after HBB administration, assessed on a 5-point scale by two blinded readers. All patients received high-spatial resolution axial T2-weighted TSE sequences at 3.0 T without spasmolytic agent, repeated after application of 40 mg HBB and followed by routine mp-MRI. Secondary endpoints were (1) susceptibility to side effects, (2) dependence of spasmolytic effect on patientsA ' weight, and (3) prostate volume.In 68% of patients, HBB significantly improved the anatomic score (mean 3.4 +/- 0.9 before and 4.4 +/- 0.7 after HBB for both readers, p = < 0.001). In 67%, HBB significantly enhanced the artefact score (mean 3.2 +/- 1 before and 4.2 +/- 0.8 after HBB for reader 1, p = < 0.001; 3.2 +/- 1 and 4.1 +/- 0.8 for reader 2, p = < 0.001). Subgroup analysis revealed no statistically significant difference between patients with different bodyweight or prostate volume. Inter-reader agreement was excellent (k = 0.95-0.98).Hyoscine butylbromide significantly improves image quality and reduces motion-related artefacts in mp-MRI of the prostate independent of bodyweight or prostate volume. No side effects were reported.aEuro cent Hyoscine butylbromide (HBB) improved image quality in over 2/3 of patients.aEuro cent Severe artefacts were reduced after HBB in more than 20%.aEuro cent The number of non-diagnostic MRI was reduced to < 1% after HBB.aEuro cent HBB effect was independent of bodyweight and prostate volume.aEuro cent No side effects of HBB were reported in this study population.