Neuroblastoma: developmental biology, cancer genomics and immunotherapy.

Neuroblastoma: developmental biology, cancer genomics and immunotherapy.
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DOI:
10.1038/nrc3526
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发表时间:
2013-06
期刊:
Nature reviews. Cancer
影响因子:
--
通讯作者:
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中科院分区:
其他
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神经母细胞瘤是一种起源于交感神经系统发育的实体瘤。在过去的十年里,我们对这种疾病的认识有了巨大的进步。未来的挑战是将所获得的知识应用于开发基于风险的治疗并最终改善结果。在这里,我们回顾了神经母细胞瘤的发育生物学,分子遗传学和免疫学的关键发现,以及将这些有前途的科学进展带入临床的新翻译工具。
Neuroblastoma is a solid tumor that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained toward developing risk-based therapies and ultimately improving outcome. Here we review the key discoveries in the developmental biology, molecular genetics, and immunology of neuroblastoma, as well as new translational tools to bring these promising scientific advances into the clinic.
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