YidC family members are involved in the membrane insertion, lateral integration, folding, and assembly of membrane proteins.
YidC family members are involved in the membrane insertion, lateral integration, folding, and assembly of membrane proteins.
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DOI：
10.1083/jcb.200405161
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发表时间：
2004-09-13
影响因子：
7.8
通讯作者：
Kuhn, Andreas
中科院分区：
文献类型：
--
作者：
Dalbey, Ross E;Kuhn, Andreas
YidC家族的成员存在于生命的所有三个领域，它们控制着各种膜蛋白复合体的组装，这些复合体起着转运蛋白、能量装置或传感器蛋白的作用。最近在细菌中的研究表明，YidC本身是一种独立于SEC蛋白传导通道的膜蛋白插入酶。YidC还可以帮助通过SEC途径插入到膜中的膜蛋白的侧向整合和折叠。
Members of the YidC family exist in all three domains of life, where they control the assembly of a large variety of membrane protein complexes that function as transporters, energy devices, or sensor proteins. Recent studies in bacteria have shown that YidC functions on its own as a membrane protein insertase independent of the Sec protein–conducting channel. YidC can also assist in the lateral integration and folding of membrane proteins that insert into the membrane via the Sec pathway.