Enantioselective transport of amino acid through supported chiral liquid membranes
Enantioselective transport of amino acid through supported chiral liquid membranes
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DOI：
10.1016/0376-7388(93)85276-3
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发表时间：
1993-12
影响因子：
9.5
通讯作者：
M. Bryjak;J. Kozłowski;P. Wieczorek;P. Kafarski
中科院分区：
文献类型：
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作者：
M. Bryjak;J. Kozłowski;P. Wieczorek;P. Kafarski
将nopol和(2S)-(−)-甲基-1-丁醇两种手性醇固定在聚乙烯薄膜的孔中，用于盐酸氨基酸的反抗选择性转运。根据手性膜相类型和氨基酸性质的不同，渗透过程的立体选择性在0.39 ~ 1.52之间变化。考虑到氨基酸的疏水性、极性和手性程度的影响，通过分步分析来评价膜分离立体异构体的能力。本文引入了手性测度。结果表明，对映体选择性主要受手性程度的影响，其中nopol膜的对映体选择性最高。
Two chiral alcohols, nopol and (2S)-(−)-methyl-1-butanol, immobilized in the pores of a polyethylene film were used for the anantioselective transport of amino acid hydrochloride. The degree of stereoselectivity of the permeation process varied from 0.39 to 1.52 depending on both the type of the chiral membrane phase and the properties of the amino acid. The evaluation of the membrane ability to separate stereoisomers was performed by the step-by-step analysis by considering the effect of amino acids' hydrophobicity, polarity and degree of chirality. For the purpose of this paper, the chirality measure was introduced. It was demonstrated that the enantioselectivity was affected mainly by the degree of chirality, and that the nopol membrane was the most efficient one.