Amphetamine increases tyrosine kinase-B receptor expression in the dorsal striatum.
Amphetamine increases tyrosine kinase-B receptor expression in the dorsal striatum.
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安非他明会增加背侧纹状体中酪氨酸激酶 B 受体的表达。
DOI：
10.1097/01.wnr.0000195667.99842.9e
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发表时间：
2006
期刊：
影响因子：
1.7
通讯作者：
Steiner,Heinz
中科院分区：
文献类型：
--
作者：
Meredith,GloriaE;Steiner,Heinz
神经营养信号被认为是重要的神经可塑性在某些前脑区域后，精神兴奋剂暴露。在这项研究中，我们发现，重复给药安非他明（5毫克/公斤，每天一次，5天）大鼠纹状体，腹侧床核，梨状皮质的酪氨酸激酶-B受体mRNA水平显着增加。最强劲的增加酪氨酸激酶-B的表达发生在背侧的纹状体，这也表明一个单一的安非他明注射后的水平升高。这些研究结果表明，纹状体酪氨酸激酶B信号的变化可能在安非他明治疗引起的神经适应和行为变化中发挥作用。
Neurotrophic signaling is thought to be important for neuroplasticity in certain forebrain regions following psychostimulant exposure. In this study, we found that repeated administration of amphetamine (5 mg/kg, once daily, 5 days) to rats significantly increased tyrosine kinase-B receptor mRNA levels in the striatum, ventral bed nucleus, and piriform cortex. The most robust increase in tyrosine kinase-B expression occurred in dorsal aspects of the striatum, which also showed elevated levels after a single amphetamine injection. These findings indicate that changes in striatal tyrosine kinase-B signaling could play a role in neuroadaptations and behavioral changes induced by amphetamine treatment.