Natural history of oral papillomavirus infections in spouses:: A prospective Finnish HPV Family Study
Natural history of oral papillomavirus infections in spouses:: A prospective Finnish HPV Family Study
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DOI：
10.1016/j.jcv.2005.05.012
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发表时间：
2006-01-01
影响因子：
8.8
通讯作者：
Syrjänen, S
中科院分区：
文献类型：
--
作者：
Rintala, M;Grénman, S;Syrjänen, S
背景资料：生殖器人乳头瘤病毒感染的自然史是众所周知的，但几乎没有什么是已知的口腔HPV-infection. Objectiveandstudydesign的结果：为了研究自然历史的口腔HPV的配偶在随访期间331名妇女（平均25.5+/-3.4年）和131名男子（平均28.8+/-5.0年）从产科招募。从健康的口腔粘膜刮配偶在基线，2，6，12和24个月和生殖器样本进行HPV检测。结果：高危型HPV的检出率为15%~ 27%。配偶之间的基线口腔HPV状态密切相关（比值比4.3; 95%置信区间1.6-12.0; P = 0.006）。配偶一方持续口腔感染是另一方口腔HR HPV持续性的显著危险因素（比值比10.0; 95%置信区间1.5-68.7; P = 0.005）。配偶双方新发HR HPV感染的累积发生率相同，而男性似乎更快地清除感染。在单变量生存分析，合作伙伴的口腔或生殖器HPV状态，口腔性行为习惯或年龄没有预测清除或收购口腔HR HPV.Conclusion：自然历史的HPV感染在口腔粘膜模仿生殖器HPV感染。口交与口腔HPV感染无关，但配偶的持续口腔HPV感染会使另一配偶的持续口腔HPV感染风险增加10倍。(C)2005 Elsevier B. V.保留所有权利。
Background: The natural history of genital human papillomavirus infection is well known, but nearly nothing is known about the Outcome of oral HPV-infection.Objectives and study design: To study natural history of oral HPV in spouses during the follow-up 331 women (mean 25.5+/-3.4 years) and 131 men (mean 28.8+/-5.0 years) were recruited from maternity unit. Scrapings from healthy oral mucosa of spouses at baseline, 2, 6 12 and 24 months and genital samples were taken for HPV testing. HPV DNA was detected by nested PCR and confirmed by hybridization using a cocktail of 12 high-risk (HR) oligoprobes.Results: The detection rate of HR HPVs varied from 15% to 27%. Baseline oral HPV status between the spouses was closely related (odds ratio 4.3; 95% confidence interval 1.6-12.0; P = 0.006). Persistent oral infection in one spouse was a significant risk factor (odds ratio 10.0; 95% confidence interval 1.5-68.7; P = 0.005) for oral HR HPV persistence in the other partner. Cumulative incidence of new HR HPV infections was identical in both spouses, while men seemed to clear their infection more rapidly. In univariate survival analysis, the partner's oral or genital HPV status, oral sex habits or age did not predict clearance or acquisition of oral HR HPV.Conclusion: Natural history of HPV infection in oral mucosa mimics that of genital HPV infection. Oral sex had no association to oral HPV infection, but a persistent oral HPV infection of the Spouse increased the risk of persistent oral HPV infection 10-fold in the other spouse. (C) 2005 Elsevier B.V. All rights reserved.