Comparative epidemiology of sudden infant death syndrome and sudden intrauterine unexplained death
Comparative epidemiology of sudden infant death syndrome and sudden intrauterine unexplained death
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DOI：
10.1136/fn.87.2.f118
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发表时间：
2002-09-01
影响因子：
4.4
通讯作者：
Stray-Pedersen, B
中科院分区：
文献类型：
--
作者：
Froen, JF;Arnestad, M;Stray-Pedersen, B
背景资料：原因不明的产前死产和婴儿猝死综合征（SIDS）是西方世界围产期和婴儿死亡率的主要原因。他们之间的关系已经提出。作为一个等效的小岛屿发展中国家只有经尸检验证的情况下被诊断为宫内不明原因的死亡（SIUD）。目的：为了检验假设，小岛屿发展中国家和SIUD有共同的风险factors.Methods：登记包括所有死产在奥斯陆和所有婴儿死亡在奥斯陆和邻近的县，阿克尔舒斯，挪威在1986-1995年。发现76例SIUD和78例SIDS，沿着582例随机对照存活婴儿，均为单胎。比值比通过多元Logistic回归分析获得。结果：SIUD与母亲年龄大、超重/肥胖、吸烟和教育程度低有关，SIDS与母亲年龄小、吸烟、男性、多产、妊娠期蛋白尿和宫底高度超过+2 SD有关。因此，母亲年龄的影响在SIUD和SIDS中是相反的（每年调整的比值比为1.39（95%置信区间为1.17至1.66），p < 0.0005）。重度吸烟、男性和多产母亲在SIUD中的可能性低于SIDS（0.22（0.06 - 0.83）、0.22（0.07 - 0.78）和0.03（0.07 - 0.78））。
Background: Unexplained antepartum stillbirth and sudden infant death syndrome (SIDS) are major contributors to perinatal and infant mortality in the western world. A relation between them has been suggested. As an equivalent of SIDS only cases validated by post mortem examination are diagnosed as sudden intrauterine unexplained death (SIUD).Objective: To test the hypothesis that SIDS and SIUD have common risk factors.Methods: Registration comprised all stillbirths in Oslo and all infant deaths in Oslo and the neighbouring county, Akershus, Norway during 1986-1995. Seventy six cases of SIUD and 78 of SIDS were found, along with 582 random controls surviving infancy, all singletons. Odds ratios were obtained by multiple logistic regression analysis.Results: Whereas SIUD was associated with high maternal age, overweight/obesity, smoking, and low education, SIDS was associated with low maternal age, smoking, male sex, multiparity, proteinuria during pregnancy, and fundal height exceeding +2 SD. Thus the effects of maternal age were opposite in SIUD and SIDS (adjusted odds ratio 1.39 (95% confidence interval 1.17 to 1.66) per year, p < 0.0005). Heavy smoking, male sex, and a multiparous mother was less likely in SIUD than in SIDS (0.22 (0.06 to 0.83), 0.22 (0.07 to 0.78), and 0.03 (