Genes for beta chain of human T-cell antigen receptor map to regions of chromosomal rearrangement in T cells.
Genes for beta chain of human T-cell antigen receptor map to regions of chromosomal rearrangement in T cells.
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人类 T 细胞抗原受体 β 链的基因映射到 T 细胞中染色体重排的区域。
DOI：
10.1126/science.3983642
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Seidman,JG
中科院分区：
文献类型：
--
作者：
Morton,CC;Duby,AD;Eddy,RL;Shows,TB;Seidman,JG
T细胞抗原受体是参与免疫应答的细胞表面分子。在本实验中，发现编码T细胞受体β链的基因位于人7号染色体长臂上q32带处或附近。在一些实验中，在第7号染色体短臂的p15-21带中发现了相关序列。以前在正常个体和共济失调毛细血管扩张症患者的T细胞中，在β链基因的这些图谱分配处和附近观察到染色体重排。
The T-cell antigen receptor is a cell-surface molecule that participates in the immune response. In the present experiments the genes encoding the β chain of the T-cell receptor were found to reside on the long arm of human chromosome 7 at or near band q32. Related sequences were found on the short arm of chromosome 7 in bands p15-21 in some experiments. Chromosomal rearrangements in T-cells from normal individuals and patients with ataxia telangiectasia have previously been observed at and near these map assignments for the β-chain genes.