Assessment of in vivo MR imaging compared to physical sections in vitro - A quantitative study of brain volumes using stereology
Assessment of in vivo MR imaging compared to physical sections in vitro - A quantitative study of brain volumes using stereology
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DOI：
10.1016/j.neuroimage.2005.01.005
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发表时间：
2005-05-15
期刊：
影响因子：
5.7
通讯作者：
Pakkenberg, B
中科院分区：
文献类型：
--
作者：
Jelsing, J;Rostrup, E;Pakkenberg, B
本研究的目的是比较体视学估计的脑体积在体内获得的磁共振成像（MRI）相应的体积从体外的物理切片。使用3-T扫描仪对10头家猪的脑进行成像。不同的脑区室的体积从MR图像由两个观察者和从物理切片使用Cavalieri估计结合点计数。配对t检验显示，两种方法之间没有显着差异的任何五个隔室考虑，除了基底灰室。然而，虽然观察者内MRI估计值的差异是可以接受的，但观察者间的差异是不可接受的。观察员之间观察到所有隔室体积估计值的统计学显著差异为11- 41%。该研究表明，定量MRI易受观察者依赖性图像解释的影响。0 2005 Elsevier Inc. All rights reserved.
The object of the present study was to compare stereological estimates of brain volumes obtained in vivo by magnetic resonance imaging (MRI) to corresponding volumes from physical sections in vitro. Brains of ten domestic pigs were imaged using a 3-T scanner. The volumes of different brain compartments were obtained from MR images by two observers and from physical sections using the Cavalieri estimator in combination with point counting. Paired t tests revealed no significant differences between the two methods for any of the five compartments considered, except for the basal gray compartment. However, although intraobserver difference of MRI estimates was acceptable, the interobserver difference was not. A statistical highly significant difference of 11-41 % was observed between observers for volume estimates of all compartments considered. The study demonstrates that quantitative MRI is susceptible to observer dependent interpretation of images. 0 2005 Elsevier Inc. All rights reserved.