1,25-dihydroxyvitamin D-3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats
1,25-dihydroxyvitamin D-3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats
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DOI：
10.1038/ki.1996.283
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发表时间：
1996-07-01
影响因子：
19.6
通讯作者：
Slatopolsky, E
中科院分区：
文献类型：
--
作者：
Denda, M;Finch, J;Slatopolsky, E
慢性肾衰竭患者和动物甲状旁腺中1,25-二羟基维生素D-3受体（VDR）含量的降低与继发性甲状旁腺功能亢进的发病机制有关。在这些研究中，我们检测了1,25-二羟基维生素D-3 （1,25-D-3）和22-氧骨化三醇（OCT）对尿毒症大鼠甲状旁腺VDR的调节作用。肾功能衰竭8周后，尿毒症大鼠甲状旁腺VDR含量降低（400 +/- 42比正常对照组729 +/- 47 fmol/mg蛋白，P < 0.05），且与血清1,25- d -3水平密切相关（r = 0.829, P = 0.0001）。1,25- d -3或OCT治疗均可阻止VDR的降低。我们得出结论，低血清1,25- d -3水平，至少在一定程度上，解释了尿毒症大鼠甲状旁腺VDR含量的下降，而1,25- d -3或OCT治疗可以防止这种下降，改善继发性甲状旁腺功能亢进的发展。
Decreased content of the 1,25-dihydroxyvitamin D-3 receptor (VDR) in parathyroid glands from patients and animals with chronic renal failure has been implicated in the pathogenesis of secondary hyperparathyroidism. In these studies, we examined the regulation of VDR by 1,25-dihydroxyvitamin D-3 (1,25-D-3) and 22-oxacalcitriol (OCT) in parathyroid glands of uremic rats. After eight weeks of renal failure, VDR content in parathyroid glands of uremic rats was decreased (400 +/- 42 vs. 729 +/- 47 fmol/mg protein in normal control rats, P < 0.05) and strongly correlated with serum 1,25-D-3 levels (r = 0.829, P = 0.0001). Treatment with either 1,25-D-3 or OCT prevented the decrease in VDR. We conclude that low serum 1,25-D-3 levels, at least in part, account for the decrease in VDR content in parathyroid glands of uremic rats and that treatment with 1,25-D-3 or OCT prevents this decrease ameliorating the development of secondary hyperparathyroidism.