Frequency and risk factors for pterygium in the Barbados Eye Study
Frequency and risk factors for pterygium in the Barbados Eye Study
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DOI：
10.1001/archopht.119.12.1827
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发表时间：
2001-12-01
影响因子：
--
通讯作者：
Leske, MC
中科院分区：
文献类型：
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作者：
Luthra, R;Nemesure, BB;Leske, MC
目的：描述巴巴多斯眼科研究中以黑人为主的人群中翼状胬肉的分布和危险因素，该研究基于40至84岁之间的巴巴多斯出生公民的随机样本。方法：标准化方案包括眼科和其他测量、自动视野测量、晶状体分级、眼底摄影和详细访谈。10%的参与者和符合特定标准的参与者也接受了全面的眼科评估。结果：巴巴多斯眼科研究纳入4709名参与者，其中2978人被转诊进行眼科评估，2781人（93%）完成检查。2617名黑人中有23.4%，97名混血（黑人和白人）中有23.7%，59名白人中有10.2%的人患有翼状胬肉。除了非洲血统外，逻辑回归分析显示，翼状胬肉与年龄（比值比[OR]， 1.01； 95%可信区间[CI]， 1.00-1.02）、受教育年限较短（OR, 1.43; 95% CI, 1.01-2.03）和户外工作地点（OR, 1.87; 95% CI, 1.52-2.29）呈正相关。肤色较深（OR, 0.66; 95% CI, 0.52-0.83）、经常在户外佩戴太阳镜（OR, 0.18; 95% CI, 0.06-0.59）和使用处方眼镜（OR, 0.75; 95% Cl, 0.60-0.93）是保护因素。结论：大约四分之一的黑人参与者患有翼状胬肉，在巴巴多斯眼科研究和其他地方，这种频率比白人高2.5到3倍。在户外工作的人患翼状胬肉的几率几乎是在户外工作的人的两倍，而在户外总是戴太阳镜的人患翼状胬肉的几率只有在户外工作的人的五分之一。通过教育干预来改变这些潜在的暴露可能有助于预防翼状胬肉。
Objective: To describe the distribution and risk factors for pterygium in the predominantly black population of the Barbados Eye Study, which was based on a random sample of Barbadian-born citizens between the ages of 40 and 84 years.Methods: The standardized protocol included ophthalmic and other measurements, automated perimetry, lens gradings, fundus photography, and a detailed interview. A 10% systematic sample of participants and those meeting specific criteria also received a comprehensive ophthalmologic evaluation.Results: The Barbados Eye Study included 4709 participants, of whom 2978 were referred for an ophthalmologic evaluation and 2781 (93%) completed the examination. Cases of pterygium were found among 23.4% of 2617 black, 23.7% of 97 mixed (black and white), and 10.2% of 59 white participants examined. In addition to African ancestry, logistic regression analyses indicated a positive association between pterygium and age (odds ratio [OR], 1.01; 95% confidence interval [CI], 1.00-1.02), fewer years of education (OR, 1.43; 95% CI, 1.01-2.03), and an outdoor job location (OR, 1.87; 95% CI, 1.52-2.29). Having a darker skin complexion (OR, 0.66; 95% CI, 0.52-0.83), always using sunglasses outdoors (OR, 0.18; 95% CI, 0.06-0.59), and the use of prescription glasses (OR, 0.75; 95% Cl, 0.60-0.93) were protective factors.Conclusions: Approximately one quarter of the black participants examined had pterygia, a frequency that was 2.5 to 3 times higher than among whites in the Barbados Eye Study and elsewhere. Pterygium was almost twice as frequent among persons who worked outdoors but was only one fifth as likely among those who always used sunglasses outdoors. Educational interventions to modify these potential exposures may assist in preventing pterygium.