Imaging performance of phase-contrast breast computed tomography with synchrotron radiation and a CdTe photon-counting detector
Imaging performance of phase-contrast breast computed tomography with synchrotron radiation and a CdTe photon-counting detector
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DOI：
10.1016/j.ejmp.2016.04.011
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发表时间：
2016-05-01
影响因子：
3.4
通讯作者：
Russo, P.
中科院分区：
文献类型：
--
作者：
Sarno, A.;Mettivier, G.;Russo, P.
目的：在基于ELETTRA同步辐射（SR）设施的syma -CT合作中，作者研究了用于女性乳房单色体内三维成像的相对比计算机断层扫描（CT）系统的成像性能，用于乳腺癌诊断。方法：使用单色SR和高分辨率CdTe光子计数检测器在38 keV下对测试对象进行成像。利用调制传递函数（MTF）和噪声功率谱对信号和噪声性能进行了评价。分别对采用相位检索算法和不采用相位检索算法的图像进行分析。对比噪声比（CNR）和检测微钙化团簇和软团块的能力进行了研究。结果：对于体素大小为（60 mu m）(3)的图像，未进行相位检索的图像在10% MTF下的空间分辨率（6.7 mm(-1)）高于进行相位检索的图像（2.5 mm(-1)）。与原始相对比图像相比，相位检索产生了噪声水平的降低和CNR的增加超过一个数量级。在两种类型的图像中都可以检测到直径低至130 μ m的微钙化。结论：对测试对象的调查表明，单色SR源乳腺CT在空间分辨率、图像噪声和对比度方面技术上是可行的，其在体内三维成像的剂量可与双视图乳房x线摄影相当。相位检索算法获得的图像在空间分辨率和图像噪声的权衡方面表现出最好的性能。(C) 2016年意大利医药工业协会。Elsevier Ltd.出版。版权所有。
Purpose: Within the SYRMA-CT collaboration based at the ELETTRA synchrotron radiation (SR) facility the authors investigated the imaging performance of the phase-contrast computed tomography (CT) system dedicated to monochromatic in vivo 3D imaging of the female breast, for breast cancer diagnosis.Methods: Test objects were imaged at 38 keV using monochromatic SR and a high-resolution CdTe photon-counting detector. Signal and noise performance were evaluated using modulation transfer function (MTF) and noise power spectrum. The analysis was performed on the images obtained with the application of a phase retrieval algorithm as well as on those obtained without phase retrieval. The contrast to noise ratio (CNR) and the capability of detecting test microcalcification clusters and soft masses were investigated.Results: For a voxel size of (60 mu m)(3), images without phase retrieval showed higher spatial resolution (6.7 mm(-1) at 10% MTF) than corresponding images with phase retrieval (2.5 mm(-1)). Phase retrieval produced a reduction of the noise level and an increase of the CNR by more than one order of magnitude, compared to raw phase-contrast images. Microcalcifications with a diameter down to 130 mu m could be detected in both types of images.Conclusions: The investigation on test objects indicates that breast CT with a monochromatic SR source is technically feasible in terms of spatial resolution, image noise and contrast, for in vivo 3D imaging with a dose comparable to that of two-view mammography. Images obtained with the phase retrieval algorithm showed the best performance in the trade-off between spatial resolution and image noise. (C) 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.