Long-term outcomes of basic fibroblast growth factor treatments in patients with vocal fold scarring, aged vocal fold, and sulcus vocalis.
Long-term outcomes of basic fibroblast growth factor treatments in patients with vocal fold scarring, aged vocal fold, and sulcus vocalis.
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基础成纤维细胞生长因子治疗声带疤痕、老年声带和声带沟患者的长期结果。
DOI：
10.1016/j.anl.2021.02.004
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
S. Chitose
中科院分区：
文献类型：
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作者：
S. Sueyoshi;H. Umeno;T. Kurita;M. Fukahori;S. Chitose
在声带瘢痕、老年声带和声带沟的患者中观察到声带粘膜的纤维化变化，这通常导致严重的嗓音障碍。以前的研究表明，碱性成纤维细胞生长因子（B FGF）改善声带特性的变化[1，2]。尽管已经进行了B FGF治疗的临床研究[3，4，5]，但这些研究仅证明了该药物在短时间内的疗效。本研究是第一次调查的长期疗效的B FGFtreatment.Methodsb FGF注射进行了6例患者从2016年1月至2017年12月在我们的机构。患者随访在最后一次注射后持续至少两年。声带瘢痕3例，老年性声带萎缩2例，声带沟1例。每个声带注射10 µg B FGF 4次。术后（1个月、3个月、6个月、1年、2年）进行语音和频闪检查。分别检测治疗前和治疗后各时间点的基频、最大发声时间（MPT）、平均流速（MFR）、振幅扰动商（APQ）、音高扰动商（PPQ）、噪声谐波比（NHR）和嗓音障碍指数（VHI-10），并进行统计学比较。其中显著的差异表明声带中音量的增加。空气动力学参数也有小幅改善。其中以声学参数的改善最为显著，表明该疗法能改善声带的对称性和规律性振动。声带振动的对称性和规律性的实现，说明声带的性质发生了变化。因此，VHI-10的评分有所改善，表明高患者满意度与此treatment.Conclusionb FGF注射液可能是一个可靠的治疗选择恶化的性质声带疾病。
ObjectiveFibrotic changes in the vocal fold mucosa have been observed in patients with vocal fold scarring, aged vocal fold, and sulcus vocalis, which often lead to severe voice disorders. Previous research suggests that the basic fibroblast growth factor (b FGF) improves variations in vocal fold properties [1,2]. Although clinical studies on b FGF treatments have been conducted [3,4,5], these studies only demonstrated the efficacy of this drug over a short period. The present study is the first to investigate the long-term efficacy of b FGF treatment.Methodsb FGF injections were performed in six patients from January of 2016 to December of 2017 at our institution. Patient follow-up continued for at least two years after the last injection. Three patients had vocal fold scarring, two had aged vocal fold atrophy, and one patient had sulcus vocalis. Each vocal fold was injected with 10 µg of b FGF four times. Voice and stroboscopic examinations were performed after surgery (at one month, three months, six months, one year, two years). Fundamental frequency, maximum phonation time (MPT), mean flow rate (MFR), amplitude perturbation quotient (APQ), pitch perturbation quotient (PPQ), and noise-to-harmonic ratio (NHR), and voice handicap index-10 (VHI-10) were examined and compared statistically between the pretreatment time and at each posttreatment time point.ResultsThe speaking F0 had an obvious decreasing tendency, with significant differences suggesting the increase in volume in the vocal folds. Aerodynamic parameters also showed small improvements. The most remarkable improvement was observed in the acoustic parameters, indicating that the treatment could improve the vocal fold to make vibrations symmetrically and regularly for a long period. Achievement of symmetry and regularity on vocal fold vibrations suggested the property changes had happened in the vocal folds. Consequently, the score of VHI-10 had improved, indicating high patient satisfaction with this treatment.Conclusionb FGF injections could be a reliable treatment option for diseases that deteriorate the property of vocal fold.
使用或不使用生长因子的声带疤痕的手术治疗。
DOI：
--
发表时间：
2021
期刊：
影响因子：
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作者：
Shinaoka Akira;Koshimune Seijiro;Yamada Kiyoshi;Kumagishi Kanae;Suami Hiroo;Kimata Yoshihiro;Ohtsuka Aiji;Hirano S
通讯作者：
Hirano S