Complex dynamics of human red blood cell flickering: alterations with in vivo aging.
Complex dynamics of human red blood cell flickering: alterations with in vivo aging.
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DOI：
10.1103/physreve.78.020901
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发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
Goldberger AL
中科院分区：
文献类型：
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作者：
Costa M;Ghiran I;Peng CK;Nicholson-Weller A;Goldberger AL
人类红细胞（RBC）表现出振动运动，称为“闪烁”。它们的动力学性质，经典的归因于热机制，还没有得到充分的表征。利用去趋势波动分析和多尺度熵方法，我们表明，在相差显微镜下观察到的红细胞短期闪烁运动具有接近1/f噪声的分形标度指数，并在多个时间尺度上表现出复杂的模式。此外，这些动力学特性随着体内老化而退化，使得在循环中更长时间的较老细胞产生比新形成的细胞显著（p <0.003）更不复杂的闪烁图案。多尺度闪烁的定量评估可以提供一种测量RBC功能的方法。膜模型需要考虑这些运动的复杂特性及其随体内衰老的变化。
Human red blood cells (RBCs) exhibit vibratory motions, referred to as “flickering.” Their dynamical properties, classically attributed to thermal mechanisms, have not been fully characterized. Using detrended fluctuation analysis and multiscale entropy methods, we show that the short-term flickering motions of RBCs, observed under phase contrast microscopy, have a fractal scaling exponent close to that of 1/f noise and exhibit complex patterns over multiple time scales. Further, these dynamical properties degrade with in vivo aging such that older cells that have been in the circulation longer generate significantly (p <0.003) less complex flickering patterns than newly formed cells. Quantitative assessment of multiscale flickering may provide a way of measuring RBC functionality. Membrane models need to account for the complex properties of these motions and their changes with in vivo senescence.