Genetic diversity among avian influenza viruses.
Genetic diversity among avian influenza viruses.
复制标题
禽流感病毒的遗传多样性。
DOI：
10.1016/0042-6822(80)90059-8
复制
发表时间：
1980
期刊：
影响因子：
3.7
通讯作者：
Webster,RG
中科院分区：
文献类型：
--
作者：
Sriram,G;BeanJr,WJ;Hinshaw,VS;Webster,RG
检测了一系列Hav7Neg2亚型禽流感病毒的RNA，以确定它们的抗原相似性是否反映了它们的RNA序列的总体保守性。凝胶电泳遗传分析表明，在所有的分离物的RNA片段的显着的变异。竞争杂交分析表明，与某些基因组片段，这种变异性代表了主要的遗传差异。这些差异甚至存在于来自一个地理区域的并发分离株中。相反，对人H3N2流感病毒分离株的类似分析表明，相隔9年分离的病毒比共同传播的禽流感病毒相似得多。禽流感病毒的遗传多样性可能是由于许多不同的A型流感病毒在鸭体内的共循环及其在自然界中重组的能力。
The RNAs of a series of avian influenza viruses of the subtype Hav7Neg2 were examined to determine if their antigenic similarity reflected an overall conservation of their RNA sequences. Genetic analysis by gel electrophoresis showed a marked variability in all of the RNA segments of the isolates. Analysis by competitive hybridization indicated that with some genome segments this variability represented major genetic differences. These differences were present even among concurrent isolates from one geographical area. In contrast, similar analysis of human H3N2 influenza virus isolates showed that viruses isolated 9 years apart were much more similar than the cocirculating avian viruses. The genetic diversity in avian influenza viruses may result from the cocirculation of many different influenza A viruses in ducks and their ability to recombine in nature.