Monodisperse plasticized poly(vinyl chloride) fluorescent microspheres for selective ionophore-based sensing and extraction.
Monodisperse plasticized poly(vinyl chloride) fluorescent microspheres for selective ionophore-based sensing and extraction.
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DOI：
10.1021/ac010694
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发表时间：
2001-11
影响因子：
7.4
通讯作者：
L. Tsagkatakis;S. Peper;R. Retter;M. Bell;E. Bakker
中科院分区：
文献类型：
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作者：
L. Tsagkatakis;S. Peper;R. Retter;M. Bell;E. Bakker
介绍了一种基于自动颗粒浇注技术制备单分散塑化聚氯乙烯颗粒的简便方法。通过在粒子中掺杂离子载体和其他活性成分，这些粒子对许多离子具有高度的选择性，这完全类似于薄膜或光纤化学传感器。本文使用的方法以大约20000个颗粒/S的速度生产高单分散性的球体。浇注过程基于可重复的聚合物液滴形成和沉淀过程，颗粒在非常温和的非反应条件下形成。这使得人们可以方便地将已知量的不同活性成分合并到聚合物中。作为最初的例子，这些颗粒被掺杂三种光学传感成分，钠离子载体叔丁基杯[4]芳烃四乙酯、H+-色团ETH 5294和阴离子添加剂四[3，5-二(三氟甲基)苯基]硼酸钠。发现颗粒为球形，直径约为10微米。根据经典的光电理论，它们对钠有单独和选择性的反应，这是由荧光显微镜确定的。在相对标准偏差为1.6%的情况下，从颗粒到颗粒的传感重复性很好。这项技术可以在整体萃取过程的基础上，开发出大规模生产的化学选择性微球。
A convenient method for the preparation of monodisperse, plasticized poly(vinyl chloride) particles based on an automated particle casting technique is described. The particles are made highly selective for a number of ions by doping them with ionophores and other active components, in complete analogy to thin-film or fiber-optic chemical sensors. The approach used here produces spheres of high monodispersity at a rate of approximately 20000 particles/s. The casting process is based on a reproducible polymer drop formation and precipitation process, and the particles are formed under very mild, nonreactive conditions. This allows one to conveniently incorporate known amounts of different active components into the polymers. As an initial example, the particles are doped with three optical sensing components, the sodium ionophore tert-butylcalix[4]arene tetraethyl ester, the H+-chromoionophore ETH 5294, and the anionic additive sodium tetrakis[3,5-bis(trifluoromethyl)phenyl] borate. The particles are found to be of spherical shape with a diameter of approximately 10 microm. They respond individually and selectively to sodium according to classical optode theory, as determined by fluorescence microscopy. With a RSD of 1.6%, sensing reproducibility from particle to particle is excellent. This technique may allow the development of mass-produced chemically selective microspheres on the basis of bulk extraction processes.