The role of polymorphonuclear leucocytes in the autologous phase of nephrotoxic nephritis.
The role of polymorphonuclear leucocytes in the autologous phase of nephrotoxic nephritis.
复制标题
多形核白细胞在肾毒性肾炎自体相中的作用。
DOI：
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发表时间：
1975
影响因子：
4.6
通讯作者：
D. Peters
中科院分区：
文献类型：
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作者：
P. Naish;N. Thomson;I. Simpson;D. Peters
本文研究了中性粒细胞（PMN）在家兔肾毒性肾炎（NTN）自体期的作用。氮芥消耗循环中性粒细胞保护肾功能，免疫荧光检查显示肾小球纤维蛋白沉积减少。使用高度特异性的山羊抗PMN血清（APS）消耗循环PMN提供了类似的肾功能保护，蛋白尿和组织学和免疫荧光检查显示减少肾小球PMN浸润，毛细血管外细胞增殖和纤维蛋白沉积的虚拟情况下，非常显着的减少。虽然氮芥的保护作用可能部分是由于免疫抑制，但在APS处理的家兔中未检测到抗体应答减少。结果表明，在NTN模型中，多晶型物是主要的损伤剂，直接或间接地导致蛋白尿和肾小球纤维蛋白沉积。
The role of polymorphonuclear leucocytes (PMN) in the autologous phase of nephrotoxic nephritis (NTN) in the rabbit has been investigated. Depletion of circulating PMN by nitrogen mustard protected renal function and immunofluorescent examination showed reduction in glomerular fibrin deposition. Depletion of circulating PMN using a highly specific goat anti-PMN serum (APS) provided similar protection of renal function, highly significant reduction in proteinuria and histological and immunofluorescent examination showed reduced glomerular PMN infiltration, extracapillary cell proliferation and virtual absence of fibrin deposition. Although protection by nitrogen mustard may have been partly due to immunosuppression, no reduction in antibody response was detected in the APS-treated rabbits. The results implicate the polymorph as the principal injurious agent in this model of NTN, responsible directly or indirectly for both proteinuria and glomerular fibrin deposition.