GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
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DOI：
10.1038/nn1043
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发表时间：
2003-05-01
影响因子：
25
通讯作者：
Kullmann, DM
中科院分区：
文献类型：
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作者：
Semyanov, A;Walker, MC;Kullmann, DM
GABA(A)受体既可以调节“时相”突触抑制，也可以调节持续的“强直”信号形式。我们发现，在存在完整的GABA摄取的情况下，豚鼠海马神经元，而不是锥体细胞，表达紧张性GABA(A)受体介导的电导。这种电导在药理学上不同于自发抑制性突触后电流(IPSCs)。抑制GABA摄取导致锥体细胞表达类似的GABA(A)受体介导的紧张性电导。降低中间神经元的紧张性电导增强了它们对锥体细胞的兴奋性和抑制驱动力。这些结果表明，细胞类型依赖的紧张性抑制在调节皮质兴奋性方面发挥了作用。
GABA(A) receptors can mediate both 'phasic' synaptic inhibition and a persistent 'tonic' form of signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal interneurons, but not pyramidal cells, express a tonic GABA(A) receptor-mediated conductance. This conductance was pharmacologically distinct from spontaneous inhibitory postsynaptic currents (IPSCs). Inhibiting GABA uptake resulted in the expression of a comparable GABA(A) receptor-mediated tonic conductance in pyramidal cells. Reducing the tonic conductance in interneurons enhanced their excitability and the inhibitory drive to pyramidal cells. These results point to a role for cell type-dependent tonic inhibition in regulating cortical excitability.