Total synthesis of (±)-haouamine A
Total synthesis of (±)-haouamine A
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DOI：
10.1021/ja0602997
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发表时间：
2006-03-29
影响因子：
15
通讯作者：
Burns, NZ
中科院分区：
文献类型：
--
作者：
Baran, PS;Burns, NZ
首次报道了高度复杂和有效的抗癌药物haouamine A的全合成，通过八步序列。序列的简洁性和化学，位置和立体选择性（平面和轴向手性）的完全控制是可能的，通过发明的化学专门针对手头的问题，即级联成环过程中通过迄今未知的化学实体的茚并-四氢吡啶环系统，以及一个吡喃酮辅助缝合令人生畏的芳香环。
The first total synthesis of the highly complex and potent anticancer agent haouamine A is reported through an eight-step sequence. Brevity of the sequence and complete control of chemo-, position-, and stereoselectivity (both planar and axial chirality) were possible through the invention of chemistry specifically tailored for the problems at hand, namely a cascade annulation proceeding via a hitherto unknown chemical entity for the indeno-tetrahydropyridine ring system as well as a pyrone-assisted stitching of the daunting bent-aromatic ring.