The local and non-local components of the local field potential in awake primate visual cortex
The local and non-local components of the local field potential in awake primate visual cortex
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DOI：
10.1007/s10827-010-0223-x
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发表时间：
2010-12-01
影响因子：
1.2
通讯作者：
Gawne, Timothy J.
中科院分区：
文献类型：
--
作者：
Gawne, Timothy J.
局部场电位 (LFP) 是从插入皮层的微电极记录的模拟信号，通常频率范围约为 1 至 200 Hz。在这里，视觉刺激在清醒行为的猕猴的初级视觉皮层神经元的感受野中闪烁，并且从同一个单极微电极记录分离的单个单元（神经元）和 LFP 信号。当视觉刺激从感受野中心附近移动到边缘附近时，单个单位活动的衰减与刺激锁定（诱发）LFP 反应的衰减平行。这表明诱发的 LFP 强烈反映了局部神经元活动。然而，即使视觉刺激完全在感受野之外并且单个单位响应已降至零，诱发的 LFP 也可能很重要，尽管这种现象是可变的。 LFP 的一些非局部成分可能与先前在麻醉动物中观察到的缓慢分布或非视网膜专题 LFP 信号有关。 LFP 的诱导（未锁定刺激开始时间）分量仅对单个单元感受野内的刺激显示显着增加。虽然 LFP 主要反映局部神经元活动，但它也可以反映更远位置的神经元活动，尽管这些非局部成分通常比局部成分更可变、更慢且更弱。
The Local Field Potential (LFP) is the analog signal recorded from a microelectrode inserted into cortex, typically in the frequency band of approximately 1 to 200 Hz. Here visual stimuli were flashed on in the receptive fields of primary visual cortical neurons in awake behaving macaques, and both isolated single units (neurons) and the LFP signal were recorded from the same unipolar microelectrode. The fall-off of single unit activity as a visual stimulus was moved from near the center to near the edge of the receptive field paralleled the fall-off of the stimulus-locked (evoked) LFP response. This suggests that the evoked LFP strongly reflects local neuronal activity. However, the evoked LFP could be significant even when the visual stimulus was completely outside the receptive field and the single unit response had fallen to zero, although this phenomenon was variable. Some of the non-local components of the LFP may be related to the slow distributed, or non-retinotopic, LFP signal previously observed in anesthetized animals. The induced (not time-locked to stimulus onset) component of the LFP showed significant increases only for stimuli within the receptive field of the single units. While the LFP primarily reflects local neuronal activity, it can also reflect neuronal activity at more distant sites, although these non-local components are typically more variable, slower, and weaker than the local components.