Activity of Δ8-and Δ9-Tetrahydrocannabinol and Related Compounds in the Mouse
Activity of Δ8-and Δ9-Tetrahydrocannabinol and Related Compounds in the Mouse
复制标题
Δ8-和Δ9-四氢大麻酚及相关化合物在小鼠中的活性
作者：
HD Christensen;R. Freudenthal;J. T. Gidley;Ronald Rosenfeld;G. Boegli;L. Testino;D. Brine;C. G. Pitt;Monroe E. Wall
Δ8.-的11-羟基代谢物和Δ9-四氢大麻酚的活性高于母体化合物。Δ8-四氢大麻酚和Δ9-四氢大麻酚都被肝脏而不是大脑快速和广泛地代谢。假设11-羟基代谢物可能是四氢大麻酚的活性形式进行了讨论
The 11-hydroxy metabolites of Δ8.- and Δ9-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Δ8- and Δ9-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussed