Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care
Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care
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DOI：
10.1136/thx.2009.128082
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发表时间：
2010-11-01
期刊：
影响因子：
10
通讯作者：
Gibson, Jack E.
中科院分区：
文献类型：
--
作者：
Feary, Johanna R.;Rodrigues, Laura C.;Gibson, Jack E.
背景与全身炎症相关的合并症包括心血管疾病（CVD）、中风和糖尿病（DM）在慢性阻塞性肺疾病（COPD）患者中很常见。进行了一项研究，以量化合并症的负担，并确定第一次急性动脉血管事件的风险与COPD.Methods的个人1 204 100名成员的年龄≥ 35岁的一般人群在2005年2月25日的计算机初级保健记录进行了检索，记录每种疾病。采用多变量logistic回归分析数据。采用考克斯回归分析确定COPD患者是否具有急性心肌梗死（MI）和卒中的增加风险。结果横断面分析显示，医生诊断的COPD与CVD的增加风险相关（OR 4.98，95%CI 4.85 - 5.81; p
Background Comorbidities associated with systemic inflammation including cardiovascular disease (CVD), stroke and diabetes mellitus (DM) are common among individuals with chronic obstructive pulmonary disease (COPD). A study was undertaken to quantify the burden of comorbidity and to determine the risk of first acute arteriovascular events among individuals with COPD.Methods The computerised primary care records of 1 204 100 members of the general population aged >= 35 years on 25 February 2005 were searched for recordings of each disease. Data were analysed using multivariate logistic regression. Cox regression was used to determine whether individuals with COPD were at increased risk of acute myocardial infarction (MI) and stroke.Results Cross-sectional analyses showed that physician-diagnosed COPD was associated with increased risks of CVD (OR 4.98, 95% CI 4.85 to 5.81; p