No evidence for the effectiveness of systemic corticosteroids in acute pharyngitis, community-acquired pneumonia and acute otitis media.
No evidence for the effectiveness of systemic corticosteroids in acute pharyngitis, community-acquired pneumonia and acute otitis media.
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DOI：
10.1007/s10096-012-1747-y
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Esposito S
中科院分区：
文献类型：
--
作者：
Principi N;Bianchini S;Baggi E;Esposito S
皮质类固醇已被用于治疗感染性疾病超过50年，但是，尽管已显示它们在改善某些疾病的临床过程中非常有效，但它们在其他疾病中的作用尚未明确。尽管如此，它们仍然被相当多的医生使用。本文综述了全身性糖皮质激素在急性咽炎（AP）、社区获得性肺炎（CAP）和急性中耳炎（AOM）治疗中的作用。已经进行了一些涉及AP患者的试验，但大多数都受到方法缺陷的影响，无法得出任何明确的结论。涉及CAP患者的试验数量甚至更高，数据表明皮质类固醇可能仅在严重疾病患者中降低死亡风险。关于AOM的数据非常少，目前没有理由开皮质类固醇来治疗它。总体而言，数据显示，目前没有迹象表明全身性皮质类固醇在任何审查的疾病中普遍使用，此外，表示“高”之义需要对所有这些呼吸道感染进行高质量的研究，以确定皮质类固醇处方合理的患者。可以接受的
Corticosteroids have been used to treat infectious diseases for more than 50 years but, although it has been shown that they are highly effective in improving the clinical course of some diseases, their effects have not been clearly defined in others. Nevertheless, they are still used by a considerable number of physicians. This review analyses the role of systemic corticosteroids in the treatment of acute pharyngitis (AP), community-acquired pneumonia (CAP) and acute otitis media (AOM). A number of trials involving patients with AP have been carried out, but most are marred by methodological flaws that do not allow any firm conclusions to be drawn. The number of trials involving CAP patients is even higher, and the data suggest that corticosteroids may reduce the risk of death only in patients with severe disease. There are very few data concerning AOM, and there is currently no reason for prescribing corticosteroids to treat it. Overall, the data showed that there is, currently, no indication for the universal use of systemic corticosteroids in any of the reviewed diseases and, further, high-quality studies of all of these respiratory tract infections are needed in order to identify the patients for whom the prescription of corticosteroids is rationally acceptable.
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DOI：
10.1186/cc10103
发表时间：
2011-03-15
期刊：
Critical care (London, England)
影响因子：
--
作者：
Fernández-Serrano S;Dorca J;Garcia-Vidal C;Fernández-Sabé N;Carratalà J;Fernández-Agüera A;Corominas M;Padrones S;Gudiol F;Manresa F
通讯作者：
Manresa F
影响因子：
11.8
作者：
Bisno, AL;Gerber, MA;Schwartz, RH
通讯作者：
Schwartz, RH
影响因子：
5.1
作者：
Chonmaitree, T;Saeed, K;McCormick, DP
通讯作者：
McCormick, DP
DOI：
10.1164/rccm.200406-808oc
发表时间：
2005-02-01
影响因子：
24.7
作者：
Confalonieri, M;Urbino, R;Meduri, GU
通讯作者：
Meduri, GU
影响因子：
--
作者：
Fine, Andrew M.;Nizet, Victor;Mandl, Kenneth D.
通讯作者：
Mandl, Kenneth D.