A potential signal of Bell's palsy after parenteral inactivated influenza vaccines: reports to the Vaccine Adverse Event Reporting System (VAERS) - United States, 1991-2001
A potential signal of Bell's palsy after parenteral inactivated influenza vaccines: reports to the Vaccine Adverse Event Reporting System (VAERS) - United States, 1991-2001
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DOI：
10.1002/pds.998
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发表时间：
2004-08-01
影响因子：
2.6
通讯作者：
Chen, RT
中科院分区：
文献类型：
--
作者：
Zhou, WG;Pool, V;Chen, RT
研究目的：瑞士一种新的鼻内灭活流感疫苗最近被发现会增加贝尔麻痹的风险。我们回顾了疫苗不良事件报告系统（VAERS）中的报告，以评估胃肠外灭活流感疫苗是否方法通过检索COSTART（Coding Symbols for Thesaurus of Adverse Reaction Terms），对1991年1月1日至2001年12月31日VAERS中有关流感疫苗接种后Bell麻痹的报道进行分析搜索“面瘫”，并通过文本字符串在at tomated数据库中搜索。对每份报告的文本描述进行了审查，以验证诊断。比例报告率（PRR）计算，以帮助信号detection.Results我们发现，共197贝尔麻痹的报告后，收到流感疫苗。154例（78.2%）确诊，其中145例（94.2%）仅接种过流感疫苗。经核实的报告来自35个州; 58%的报告涉及生活在莱姆病风险低、最小或没有莱姆病风险的州的人。所有年龄组的PRR均超过了可能相关信号的标准。最高的PRR为3.91在大于或等于65岁agree.Conclusions我们的研究结果揭示了一个信号，流感疫苗和贝尔麻痹的风险增加之间可能存在关联。需要一项基于人群的对照研究来确定这种关联是否是因果关系，并量化风险。出版社：John Wiley Sons，Ltd.
Purpose Post-licens are experience with a new intranasal inactivated influenza vaccine in Switzerland recently identified an increased risk for Bell's palsy. We reviewed reports in the Vaccine Adverse Event Reporting System (VAERS) to assess if parenteral inactivated influenza vaccines (influenza vaccines) may also increase the risk for Bell's palsy.Methods Reports of Bell's palsy after influenza vaccines in VAERS from 1/1/1991 to 12/31/2001 were identified by searching the Coding Symbols for Thesaurus of Adverse Reaction Terms (COSTART) for 'paralysis facial' and by text string search in the at tomated database. The text descriptions on each report were reviewed to verify the diagnosis. The proportional reporting ratio (PRR) was calculated to aid signal detection.Results We found a total of 197 reports of Bell's palsy after receipt of influenza vaccines. The diagnosis was verified for 154 (78.2%), of which 145 (94.2%) had received influenza vaccines alone. The verified reports were submitted from 35 states; 58% of the reports involved persons living in states where the risk of Lyme disease, which can also cause facial paralysis, was low, minimal or none. The PRRs in all age groups exceeded the criteria for a signal of possible association. The highest PRR was 3.91 in the greater than or equal to65 years age group.Conclusions Our findings revealed a signal of possible association between influenza vaccines and an increased risk of Bell's palsy. A population-based controlled study is needed to determine whether this association could be causal and to quantify the risk. Published in 2004 by John Wiley Sons, Ltd.