The PedsQL™ in pediatric cancer -: Reliability and validity of the Pediatric Quality of Life Inventory™ Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module
The PedsQL™ in pediatric cancer -: Reliability and validity of the Pediatric Quality of Life Inventory™ Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module
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DOI：
10.1002/cncr.10428
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发表时间：
2002-04-01
期刊：
影响因子：
6.2
通讯作者：
Dickinson, P
中科院分区：
文献类型：
--
作者：
Varni, JW;Burwinkle, TM;Dickinson, P
背景儿科生活质量量表（PedsQL）是一种模块化工具，旨在测量2-18岁儿童和青少年的健康相关生活质量（HRQOL）。PedsQL 4.0通用核心量表是多维儿童自我报告和父母代理报告量表，开发为与PedsQL疾病特定模块集成的通用核心指标。PedsQL多维疲劳量表旨在测量儿科患者的疲劳。PedsQL 3.0癌症模块旨在测量儿科癌症特异性HRQOL。PedsQL通用核心量表、多维疲劳量表和癌症模块被应用于339个家庭（220个儿童自我报告; 337个父母代理报告）。PedsQL通用核心总量表评分（α = 0.88儿童，0.93父母报告）、多维疲劳总量表评分（α = 0.89儿童，0.92父母报告）和大多数癌症模块量表（平均α = 0.72儿童，0.87父母报告）的内部一致性可靠性证明了组比较的可靠性可接受。使用已知组方法证明了有效性。PedsQL将健康儿童和癌症儿童作为一个群体进行区分，并将治疗中的儿童与停止治疗的儿童进行区分。PedsQL多维疲劳量表的有效性通过与一般和癌症特异性HRQOL维度的假设相关性得到进一步证明。结果证明了PedsQL通用核心量表、多维疲劳量表和癌症模块在儿科癌症中的可靠性和有效性。PedsQL可用作临床试验、研究和临床实践中的结局指标。
BACKGROUND. The Pediatric Quality of Life Inventory (PedsQL) is a modular instrument designed to measure health-related quality of life (HRQOL) in children and adolescents ages 2-18 years. The PedsQL 4.0 Generic Core Scales are multidimensional child self-report and parent proxy-report scales developed as the generic core measure to be integrated with the PedsQL disease specific modules. The PedsQL Multidimensional Fatigue Scale was designed to measure fatigue in pediatric patients. The PedsQL 3.0 Cancer Module was designed to measure pediatric cancer specific HRQOL.METHODS. The PedsQL Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module were administered to 339 families (220 child self-reports; 337 parent proxy-reports).RESULTS. Internal consistency reliability for the PedsQL Generic Core Total Scale Score (alpha = 0.88 child, 0.93 parent report), Multidimensional Fatigue Total Scale Score (alpha = 0.89 child, 0.92 parent report) and most Cancer Module Scales (average alpha = 0.72 child, 0.87 parent report) demonstrated reliability acceptable for group comparisons. Validity was demonstrated using the known-groups method. The PedsQL distinguished between healthy children and children with cancer as a group, and among children on-treatment versus off-treatment. The validity of the PedsQL Multidimensional Fatigue Scale was further demonstrated through hypothesized intercorrelations with dimensions of generic and cancer specific HRQOL.CONCLUSIONS. The results demonstrate the reliability and validity of the PedsQL Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module in pediatric cancer. The PedsQL may be utilized as an outcome measure in clinical trials, research, and clinical practice.