MANNOSE-BINDING PROTEIN GENE POLYMORPHISM IN SYSTEMIC LUPUS-ERYTHEMATOSUS
MANNOSE-BINDING PROTEIN GENE POLYMORPHISM IN SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1002/art.1780380117
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发表时间：
1995-01-01
影响因子：
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通讯作者：
OLLIER, WER
中科院分区：
文献类型：
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作者：
DAVIES, EJ;SNOWDEN, N;OLLIER, WER
Objective.目的探讨不能激活补体的甘露糖结合蛋白（MBP）等位基因是否与系统性红斑狼疮（SLE）易感性相关。应用扩增难治性突变系统-聚合酶链反应技术检测102例白色SLE患者和136例对照者的MBP等位基因频率。42例SLE患者（41%）和41例对照（30%）中存在不能激活补体的MBP等位基因（P = 0.08，比值比[OR] = 1.6，95%置信区间[95% CI] 1.0-2.8）。SLE患者的等位基因频率为0.25，对照组为0.19（P = 0.08，OR = 1.5，95%CI 1.0-2.3）。我们的研究结果表明，MBP基因的等位基因是SLE的一个次要危险因素。
Objective. To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE).Methods. MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls.Results. The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3).Conclusion. Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.