Peripheral afferents and spinal inhibitory system in dynamic and static mechanical allodynia.
Peripheral afferents and spinal inhibitory system in dynamic and static mechanical allodynia.
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DOI：
10.1097/j.pain.0000000000001055
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发表时间：
2017-12
期刊：
影响因子：
7.4
通讯作者：
Chung JM
中科院分区：
文献类型：
--
作者：
La JH;Chung JM
机械性异常性疼痛是一种来自无害机械刺激（如触摸）的使人衰弱的疼痛。为了阐明其机制，一种方法是关注不同类型的传入神经介导的机械性异常性疼痛，这些疼痛来自于刺激在皮肤上的移动（例如，刷牙）和刺激“固定”在某一点（如轻轻按压或弱点状刺激）;前一种类型的异常性疼痛被称为“动态”，而后者被称为“静态”23，39（然而，这些术语通过“刺激模式”而不是通过传入类型来区分机械性异常性疼痛）。因此，由于动态和静态机械异常性疼痛之间的刺激模式不同，因此推测产生不同的传入输入，然后在脊髓中进行差异处理。在这方面，最近的文献表明，甘氨酸和g-氨基丁酸（GABA）的传输传入输入的抑制性处理之间的动态和静态的机械异常性疼痛，分别不同。36，41除了动态/静态刺激模式之外，诸如刺激区域的大小/深度（例如，大压力探针与von Frey细丝）和刺激速度/持续时间等因素也会影响机械性异常性疼痛，因为空间/时间总和、传入神经之间的抵消作用，2，34和传入神经的适应特性。由于传入输入和脊髓抑制性处理的性质似乎不同的2种类型的机械性异常性疼痛，本文综述了我们所知道的这些问题在各种病理和实验性疼痛条件。在本文中，需要注意的是，我们不涉及“机械性痛觉过敏”，即通常引起疼痛的机械刺激引起的疼痛增加。
Mechanical allodynia is a debilitating pain from innocuous mechanical stimuli such as touch. To unravel its mechanism, one approach has been to focus on the fact that different afferent types mediate mechanical allodynia from stimuli “moving” across the skin (eg, brushing) and from stimuli “fixed” on a certain spot (eg, gentle pressure or weak punctate stimulation); the former type of allodynia being designated “dynamic” and the latter,“static” 23, 39 (these terms, however, differentiate mechanical allodynia by “stimulation mode,” not by afferent type). Thus, because the stimulation mode differs between dynamic and static mechanical allodynia, different afferent inputs are presumably generated and then differentially processed in the spinal cord. In this regard, recent literature suggests that inhibitory processing of afferent inputs by glycine-and g-aminobutyric acid (GABA) transmission differs between dynamic and static mechanical allodynia, respectively. 36, 41 In addition to the dynamic/static stimulation mode, factors such as the size/depth of stimulated area (eg, large pressure probe vs von Frey filament) and the stimulation velocity/duration can influence mechanical allodynia because of spatial/temporal summation, counteraction between afferents, 2, 34 and afferents’ adaptation properties. Because the nature of afferent inputs and the spinal inhibitory processing seem to differ in the 2 types of mechanical allodynia, this review summarizes what we know of these issues in various pathological and experimental pain conditions. In this review, as a caveat, we do not deal with “mechanical hyperalgesia,” an increased pain from a mechanical stimulus that normally provokes pain.
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影响因子：
64.5
作者：
Duan B;Cheng L;Bourane S;Britz O;Padilla C;Garcia-Campmany L;Krashes M;Knowlton W;Velasquez T;Ren X;Ross S;Lowell BB;Wang Y;Goulding M;Ma Q
通讯作者：
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Foster, Edmund;Wildner, Hendrik;Tudeau, Laetitia;Haueter, Sabine;Ralvenius, William T.;Jegen, Monika;Johannssen, Helge;Hoesli, Ladina;Haenraets, Karen;Ghanem, Alexander;Conzelmann, Karl-Klaus;Boesl, Michael;Zeilhofer, Hanns Ulrich
通讯作者：
Zeilhofer, Hanns Ulrich
影响因子：
0.9
作者：
Greenspan, JD;Thomadaki, M;McGillis, SLB
通讯作者：
McGillis, SLB
影响因子：
13.3
作者：
Garrison, Sheldon R.;Stucky, Cheryl L.
通讯作者：
Stucky, Cheryl L.
影响因子：
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作者：
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