The relationship between serum cytokine levels with obesity and obstructive sleep apnea syndrome
The relationship between serum cytokine levels with obesity and obstructive sleep apnea syndrome
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DOI：
10.1016/j.cyto.2004.07.003
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发表时间：
2004-10-21
期刊：
影响因子：
3.8
通讯作者：
Bilgihan, A
中科院分区：
文献类型：
--
作者：
Ciftci, TU;Kokturk, O;Bilgihan, A
炎性细胞因子如白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）可能对葡萄糖和脂质代谢有直接影响。另一方面，已知IL-6和TNF-α是动脉粥样硬化发病机制中重要的促炎细胞因子。本研究的目的是测试睡眠呼吸暂停是否有助于先前报道的独立于肥胖的IL-6和TNF-α的增加。43名肥胖（体重指数，BMI > 27 kg/m2）男性，新诊断为阻塞性睡眠呼吸暂停综合征（OSAS）（呼吸暂停低通气指数，AHI ≥ 5），22名年龄和BMI匹配的肥胖非呼吸暂停男性对照（AHI G5）入选本研究。为了确诊，所有患者都在睡眠障碍中心接受了标准的多导睡眠图检查。空腹过夜后，于早晨08：00采集血清样本。OSAS患者血清IL-6和TNF-α水平显著高于对照组（p = 0.002，p = 0.03）。OSAS患者血清IL-6和TNF-α水平与AHI显著相关（r = 0.03，p = 0.046和r = 0.36，p = 0.016）。对照组血清IL-6、TNF-α水平与AHI无明显相关性。OSAS患者和对照组血清IL-6和TNF-α水平与BMI均无相关性。总之，OSAS患者的循环IL-6和TNF-α水平与BMI无关，显著高于对照组水平，并且上述细胞因子水平与OSAS的严重程度呈正相关。根据这些结果，心血管发病率和OSAS之间的联系可以通过其他心血管危险因素如循环IL-6和TNF-α水平的共存来解释。(C)2004 Elsevier Ltd.保留所有权利。
Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) may have a direct effect on glucose and lipid metabolism. On the other hand, it is known that IL-6 and TNF-alpha are important pro-inflammatory cytokines in the pathogenesis of atherosclerosis. The goal of present study was to test whether sleep apnea contributes to the previously reported increases of IL-6 and TNF-alpha independent of obesity. Forty-three obese (body mass index, BMI > 27 kg/m(2)) men with newly diagnosed obstructive sleep apnea syndrome (OSAS) (apnea-hypopnea index, AHI greater than or equal to 5) and age- and BMI-matched 22 obese nonapneic male controls (AHI G 5) were enrolled in this study. To confirm the diagnosis, all patients underwent standard polysomnography in the sleep disorders center. Serum samples were taken at 08:00 h in the morning after overnight fasting. Serum IL-6 and TNF-alpha levels were found significantly higher in OSAS patients than in controls (p = 0.002, p = 0.03). Serum IL-6 and TNF-a levels were significantly correlated with AHI in OSAS patients (r = 0.03, p = 0.046 and r = 0.36, p = 0.016). There was no significant correlation between serum IL-6, TNF-alpha levels and AHI in controls. Serum IL-6 and TNF-alpha levels were not correlated with BMI both in OSAS patients and controls. In conclusion, circulating IL-6 and TNF-alpha levels in patients with OSAS, as independent of BMI are significantly higher than levels in controls and there is a positive relationship between previously mentioned cytokines' levels and the severity of OSAS. According to these results, the link between cardiovascular morbidity and OSAS may be explained by the coexistence of other cardiovascular risk factors such as circulating IL-6 and TNF-a levels. (C) 2004 Elsevier Ltd. All rights reserved.