IL5RA polymorphisms, smoking, and eczema in Japanese women: The Kyushu Okinawa Maternal and Child Health Study.
IL5RA polymorphisms, smoking, and eczema in Japanese women: The Kyushu Okinawa Maternal and Child Health Study.
复制标题
日本女性的 IL5RA 多态性、吸烟和湿疹：九州冲绳母婴健康研究。
DOI：
10.1111/iji.12172
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Arakawa M.
中科院分区：
文献类型：
--
作者：
Miyake Y;Tanaka K;Arakawa M.
本病例对照研究探讨了il5rasnps与日本年轻成年女性湿疹之间的关系。病例和对照对象是从参加九州冲绳母婴健康研究基线调查的孕妇中选择的，该研究是一项正在进行的产前队列研究。根据国际儿童哮喘和过敏研究（ISAAC）的标准，188名妇女在过去12个月内患有湿疹，无论是否有医生诊断为特应性湿疹。对照对象包括1130名根据ISAAC标准定义的未患湿疹且未被医生诊断为特应性湿疹的女性。与AA基因型fil5rasnp rs17881144相比，AT基因型与湿疹风险降低显著相关，而TT基因型与湿疹风险降低显著相关。rs17882210、rs3804797、rs334809、rs9831572、rs6771148和rs17881144的ATTAGA单倍型和GTAGCA单倍型与湿疹风险增加显著相关。相反，GCTGCA单倍型与湿疹风险降低显著相关。il5rasnps rs334809和rs17881144与吸烟之间关于湿疹的倍增相互作用具有边际显著性（P分别=0.07和0.07）。这是首次发现il5rasnp rs17881144、ATTAGA单倍型、GTAGCA单倍型和GCTGCA单倍型与湿疹之间存在显著关联的研究。吸烟可能改变snp rs334809和rs17881144与湿疹的关系。
The present case–control study examined the relationship betweenIL5RASNPs and eczema in young adult Japanese women. Cases and control subjects were selected from pregnant women who participated in the baseline survey of the Kyushu Okinawa Maternal and Child Health Study, which is an ongoing prebirth cohort study. Cases comprised 188 women with eczema in the previous 12 months as defined according to the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC), regardless of the presence of a doctor's diagnosis of atopic eczema. Control subjects comprised 1130 women without eczema as defined according to the ISAAC criteria who also had not been diagnosed with atopic eczema by a doctor. Compared with the AA genotype ofIL5RASNP rs17881144, the AT genotype, but not the TT genotype, was significantly associated with a decreased risk of eczema. The ATTAGA haplotype and the GTAGCA haplotype of rs17882210, rs3804797, rs334809, rs9831572, rs6771148 and rs17881144 were significantly associated with an increased risk of eczema. In contrast, the GCTGCA haplotype was significantly related to a decreased risk of eczema. Multiplicative interactions betweenIL5RASNPs rs334809 and rs17881144 and smoking with respect to eczema were marginally significant (P=0.07 and 0.07, respectively). This is the first study to show significant associations betweenIL5RASNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema. Smoking may modify the relationships between SNPs rs334809 and rs17881144 and eczema.