Mash1 is required for the differentiation of AADC‐positive type III cells in mouse taste buds
Mash1 is required for the differentiation of AADC‐positive type III cells in mouse taste buds
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DOI：
10.1002/dvdy.22576
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发表时间：
2011-04
影响因子：
2.5
通讯作者：
Y. Seta;M. Oda;Shinji Kataoka;T. Toyono;K. Toyoshima
中科院分区：
文献类型：
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作者：
Y. Seta;M. Oda;Shinji Kataoka;T. Toyono;K. Toyoshima
Mash 1在中枢神经系统和外周神经系统的神经元前体亚群中表达。然而，Mash 1参与味觉细胞分化以前没有被证明。在这项研究中，我们调查了Mash 1基因敲除小鼠在调节味蕾分化的作用，开始了解调控味蕾细胞分化的机制。我们发现芳香族L-氨基酸脱羧酶（AADC）细胞在Mash 1 KO小鼠软腭的轮廓乳头上皮或味蕾中均不明显。然而，味蛋白在Mash 1 KO小鼠的软腭中的味蕾中表达。这些结果表明，Mash 1在调节味蕾III型细胞中AADC的表达中起重要作用，这支持了不同味蕾细胞类型具有对每种细胞类型特异性的祖细胞的假设。Developmental Dynamics 240：775-784，2011.© 2011 Wiley‐利斯公司
Mash1 is expressed in subsets of neuronal precursors in both the central nervous system and the peripheral nervous system. However, involvement of Mash1 in taste cell differentiation has not previously been demonstrated. In this study, we investigated the role of Mash1 in regulating taste bud differentiation using Mash1 KO mice to begin to understand the mechanisms that regulate taste bud cell differentiation. We found that aromatic L‐amino acid decarboxylase (AADC) cells were not evident in either the circumvallate papilla epithelia or in taste buds in the soft palates of Mash1 KO mice. However gustducin was expressed in taste buds in the soft palates of Mash1 KO mice. These results suggest that Mash1 plays an important role in regulating the expression of AADC in type III cells in taste buds, which supports the hypothesis that different taste bud cell types have progenitor cells that are specific to each cell type. Developmental Dynamics 240:775–784, 2011. © 2011 Wiley‐Liss, Inc.