METAMORPHOSIS OF THE CENTRAL-NERVOUS-SYSTEM OF DROSOPHILA
METAMORPHOSIS OF THE CENTRAL-NERVOUS-SYSTEM OF DROSOPHILA
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DOI：
10.1002/neu.480210711
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发表时间：
1990-10-01
期刊：
影响因子：
--
通讯作者：
TRUMAN, JW
中科院分区：
文献类型：
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作者：
TRUMAN, JW
果蝇中枢神经系统变态的研究集中在腹侧中枢神经系统。许多幼虫神经元在变态过程中是保守的，但它们显示出明显的中枢和外周突起的重塑。一般来说，递质的表达在变态过程中似乎是保守的，但也有一些可能的变化。大量新的、成虫特有的神经元被添加到这个持久幼虫细胞的基本组成中。这些细胞是在幼虫生命期间由持续到幼虫阶段的胚胎神经母细胞产生的。这些新的神经元在出生后不久就停止了发育，但随后在变态过程中成熟为功能神经元。程序性细胞死亡对塑造成人中枢神经系统也很重要。一轮细胞死亡发生在羽化后不久，第二轮细胞死亡发生在成虫羽化后。
The study of the metamorphosis of the central nervous system ofDrosophilafocused on the ventral CNS. Many larval neurons are conserved through metamorphosis but they show pronounced remodeling of both central and peripheral processes. In general, transmitter expression appears to be conserved through metamorphosis but there are some examples of possible changes. Large numbers of new, adult‐specific neurons are added to this basic complement of persisting larval cells. These cells are produced during larval life by embryonic neuroblasts that had persisted into the larval stage. These new neurons arrest their development soon after their birth but then mature into functional neurons during metamorphosis. Programmed cell death is also important for sculpting the adult CNS. One round of cell death occurs shortly after pupariation and a second one after the emergence of the adult fly.