Electrically evoked electroretinograms and pupil responses in Argus II retinal implant wearers.
Electrically evoked electroretinograms and pupil responses in Argus II retinal implant wearers.
复制标题
Argus II 视网膜植入佩戴者的电诱发视网膜电图和瞳孔反应。
DOI：
10.1007/s10633-015-9522-x
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Dagnelie,Gislin
中科院分区：
文献类型：
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作者：
Stronks,HChristiaan;Barry,MichaelP;Dagnelie,Gislin
目的观察终末期视网膜色素变性患者眼电诱发视网膜电图（eERG）和闪光ERG的变化，以评价视网膜对局部电刺激的反应特性。此外，我们记录瞳孔直径在电stimulation.MethodsRaw角膜eERG记录在多个刺激水平在三个科目。eERG信号被各种伪影严重污染，包括植入电子器件产生的切换伪影、刺激、眨眼和眼动伪影。瞳孔反应被记录在一个主题使用瞳孔tracker.ResultseERG被净化的各种技术，包括小波变换和响应平均。主要分量是峰值约为200 ms的负波。eERG振幅与刺激强度显著相关，而峰潜伏期与刺激强度无相关性。瞳孔收缩与刺激水平和瞳孔反应显着相关，可以准确地用来估计主观threshold.ConclusioneERG记录有可能被进一步开发为视网膜植入物作为一种诊断工具。增加eERG振幅的直接方法是开发基于反向遥测的眼内记录方法。一名受试者对电刺激的强烈瞳孔反应表明，瞳孔描记术可用于评估植入物功能，但无法在所有受试者中获得可靠的瞳孔记录。
PurposeWe have recorded the electrically evoked electroretinogram (eERG) and flash ERG in Argus II retinal prosthesis wearers with end-stageretinitis pigmentosato estimate response properties of the degenerated inner retina to local electrical stimulation. In addition, we have recorded pupil diameters during electrical stimulation.MethodsRaw corneal eERGs were recorded at multiple stimulus levels in three subjects. eERG signals were heavily contaminated with various artifacts, including switching artifacts generated by the implant electronics, stimulus, blink, and eye-movement artifacts. Pupil responses were recorded in one subject using a pupil tracker.ResultseERGs were decontaminated by a variety of techniques, including wavelet transformation and response averaging. The dominant component was a negative wave peaking at approximately 200 ms. eERG amplitudes correlated significantly with stimulus level, but peak latencies did not correlate with stimulus level. Pupil constriction correlated significantly with stimulus level and pupil responses could be accurately used to estimate subjective threshold.ConclusioneERG recordings hold the potential to be developed further for use as a diagnostic tool for retinal implants. A straightforward approach to increase eERG amplitudes would be the development of intraocular recording methods based on reverse telemetry. The robust pupil response to electrical stimulation in one subject indicates that pupillography can be exploited to assess implant functionality, but reliable pupil recordings could not be obtained in all subjects.