A set of genes expressed in response to light in the adult cerebral cortex and regulated during development
A set of genes expressed in response to light in the adult cerebral cortex and regulated during development
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DOI：
10.1073/pnas.93.5.2048
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发表时间：
1996-03-05
影响因子：
11.1
通讯作者：
Hevroni, D
中科院分区：
文献类型：
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作者：
Nedivi, E;Fieldust, S;Hevroni, D
活动依赖的可塑性被认为是发育过程中形成适当的突触连接和成年皮层地形图重组的基础，我们最近克隆了许多由谷氨酸受体激活诱导的海马可塑性相关基因（CPGs）。筛选CPG库中可能有助于新皮层可塑性的基因，导致鉴定出在成人视觉皮层区域中响应于光而被诱导的六个基因。这些基因在出生后皮层发育期间也被自然诱导，通过视觉刺激的CPG诱导主要发生在位于皮质层II-III和VI中的神经元中，并且持续至少48小时。（cpg 2，cpg 15，cpg 22，cpg 29）是以前未报道的基因，其中一个（cpg 2）预测了“mini-dystrophin-like”结构蛋白。这些结果为成年人大脑皮层活动依赖性结构重组的生理学和解剖学研究提供了分子遗传学支持。此外，这些结果还为成年人大脑皮层重组机制的功能提供了候选基因。
Activity-dependent plasticity is thought to underlie both formation of appropriate synaptic connections during development and reorganization of adult cortical topography, We have recently cloned many candidate plasticity-related genes (CPGs) induced by glutamate-receptor activation in the hippocampus. Screening the CPG pool for genes that may contribute to neocortical plasticity resulted in the identification of six genes that are induced in adult visual cortical areas in response to light, These genes are also naturally induced during postnatal cortical development, CPG induction by visual stimulation occurs primarily in neurons located in cortical layers II-III and VI and persists for at least 48 hr. Four of the visually responsive CPGs (cpg2, cpg15, cpg22, cpg29) are previously unreported genes, one of which (cpg2) predicts a ''mini-dystrophin-like'' structural protein. These results lend molecular genetic support to physiological and anatomical studies showing activity-dependent structural reorganization in adult cortex, In addition, these results provide candidate genes the function of which may underlie mechanisms of adult cortical reorganization.