Transcriptional regulation of CCL20 expression
Transcriptional regulation of CCL20 expression
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CCL20 表达的转录调控
DOI：
10.1016/j.micinf.2014.08.005
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发表时间：
2014-10-01
影响因子：
5.8
通讯作者：
Xu, Feng
中科院分区：
文献类型：
--
作者：
Zhao, Lifang;Xia, Jingyan;Xu, Feng
趋化因子是免疫调节和促炎反应过程中白细胞募集的关键介质。CCL 20是一种半胱氨酸趋化因子，最初被证明对未成熟树突状细胞、效应或记忆CD 4（+）T淋巴细胞和B淋巴细胞具有趋化性。此外，CCL 20及其唯一受体（CCR 6）被癌细胞用于迁移和转移扩散，并在癌症的发展和进展中发挥重要作用。然而，CCL 20/CCR 6轴的活性如何在转录水平上被控制和调节仍不清楚。CCL 20启动子区含有转录起始位点、核因子（NF）-κ B结合位点、CCAAT/增强子结合蛋白结合位点、激活蛋白-1结合位点和特异性蛋白1（Sp1）结合位点。在这篇综述中，我们概述了最近的进展，我们了解的CCL 20启动子区域的结构，并讨论了CCL 20启动子的转录调控。(C)2014巴斯德研究所。由Elsevier Masson SAS出版。All rights reserved.
Chemokines are key mediators of leukocyte recruitment during immunoregulatory and proinflammatory responses. CCL20 is a cysteine cysteine chemokine that was originally shown to be chemotactic for immature dendritic cells, effector or memory CD4(+) T lymphocytes, and B lymphocytes. Additionally, CCL20 and its only receptor (CCR6) are exploited by cancer cells for migration and metastatic spread and play important roles in the development and progression of cancer. However, it still remains unclear how the activity of the CCL20/CCR6 axis is controlled and regulated at the transcriptional level. The CCL20 promoter region contains a transcription start site, a nuclear factor (NF)-kappa B binding site, a CCAAT/enhancer-binding proteins binding site, an activator protein-1 binding sites, and a specificity protein 1 (Sp1)-binding site. In this review, we outline recent advances in our understanding of the structure of the CCL20 promoter region and discuss the transcriptional regulation of the CCL20 promoter. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.