Transcranial direct current stimulation disrupts tactile perception
Transcranial direct current stimulation disrupts tactile perception
复制标题
DOI：
10.1111/j.0953-816x.2004.03450.x
复制
发表时间：
2004-07-01
影响因子：
3.4
通讯作者：
Knecht, S
中科院分区：
文献类型：
--
作者：
Rogalewski, A;Breitenstein, C;Knecht, S
大脑皮层的兴奋性可以通过各种经颅刺激技术进行调节。经颅直流电刺激(Tdcs)具有便携式设备的优点，因此可用于动态调节大脑兴奋性。然而，到目前为止，tDCs对大脑皮层兴奋性的调节主要是通过间接手段进行的。因此，我们研究了tdcs是否具有直接的行为/知觉效应。我们比较了13名受试者在1 mA电流强度下，在tDCS作用7min之前、期间和之后对左手无名指的触觉辨别能力。在受试者内部设计中，刺激被伪随机分为阴极、阳极和假刺激。根据10-20脑电系统，将激活电极置于C4相应的躯体感觉皮质之上，将参比电极置于对侧眶上方的额部。阴极区刺激与假刺激相比，触觉辨别力下降的时间延长，而阴极区和假刺激区则无明显变化。因此，通过便携式技术施加微弱的经颅电流刺激，可以以行为/感知有意义的方式调节皮质处理。这一发现为以皮质兴奋性改变为特征的疾病的治疗提供了新的视角。
The excitability of the cerebral cortex can be modulated by various transcranial stimulation techniques. Transcranial direct current stimulation (tDCS) offers the advantage of portable equipment and could, therefore, be used for ambulatory modulation of brain excitability. However, modulation of cortical excitability by tDCS has so far mostly been shown by indirect measures. Therefore, we examined whether tDCS has a direct behavioral/perceptional effect. We compared tactile discrimination of vibratory stimuli to the left ring finger prior to, during and after tDCS applied for 7 min at 1-mA current intensity in 13 subjects. Stimulation was pseudorandomized into cathodal, anodal and sham conditions in a within-subject design. The active electrode was placed over the corresponding somatosensory cortex at C4 according to the 10-20 EEG system and the reference electrode at the forehead above the contralateral orbita. Cathodal stimulation compared with sham induced a prolonged decrease of tactile discrimination, while anodal and sham stimulation did not. Thus, cortical processing can be modulated in a behaviorally/perceptually meaningful way by weak transcranial current stimulation applied through portable technology. This finding offers a new perspective for the treatment of conditions characterized by alterations of cortical excitability.