The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain.
The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain.
复制标题
DOI：
10.1084/jem.165.4.1230
复制
发表时间：
1987-04-01
期刊：
影响因子：
--
通讯作者：
Riethmüller G
中科院分区：
文献类型：
--
作者：
Funke I;Hahn A;Rieber EP;Weiss E;Riethmüller G
用免疫组化和北方印迹分析法对正常人脑中CD 4抗原的表达进行了平行研究。用抗CD 4抗体检测分子的不同表位，在小脑、丘脑和脑桥中确定了CD 4+神经元。在丘脑和脑桥中发现了CD 4+胶质细胞。CD 4特异性mRNA在所有三个亚区和海马中检测到，而其他亚区为阴性。CD 4+细胞与抗T细胞抗体（抗CD 2和抗CD 8）以及抗单核细胞抗体（M-M 522和M-M 42）呈阴性。
The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamus and pons. CD4- specific mRNA was detected in all three subareas and in the hippocampus, while other subareas were negative. The CD4+ cells were negative with anti-T cell antibodies (anti-CD2 and anti-CD8), as well as with antimonocyte antibodies (M-M 522 and M-M 42).