Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes
Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes
复制标题
Tetramethylpyrazine 清除超氧阴离子并减少人多形核白细胞中一氧化氮的产生。
DOI：
10.1016/s0024-3205(03)00139-5
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发表时间：
2003-04-18
期刊：
影响因子：
6.1
通讯作者：
Xin, WJ
中科院分区：
文献类型：
--
作者：
Zhang, ZH;Wei, TT;Xin, WJ
川芎嗪是中药川芎的有效成分之一。采用电子自旋共振自旋捕集方法，研究了川芎嗪对人多形核白细胞产生超氧阴离子和一氧化氮的影响。在N=甲酰甲硫氨酰-亮氨酰-苯丙氨酸诱导的多形核白细胞呼吸爆发过程中，川芎嗪剂量依赖性地清除超氧阴离子，显著减少一氧化氮的产生，但对耗氧量无影响。上述结果提示，川芎嗪对缺血性脑损伤的保护作用可能与其清除活性氧，调节一氧化氮的生成，从而抑制过氧亚硝基阴离子的形成有关。(C)2003年爱思唯尔科学公司All rights reserved.
Tetramethylpyrazine is one of the active ingredients of the Chinese herb Ligusticum wallichii Franchat. By electron spin resonance spin trapping methods, effects of tetramethylpyrazine on superoxide anion and nitric oxide generated by human polymorphonuclear leukocytes were studied. During the respiratory burst of polymorphonuclear leukocytes induced by N=formylmethionyl-leucyl-phenylalanine, tetramethylpyrazine scavenges superoxide anion dose-dependently, and decreases the production of nitric oxide significantly, but shows no influence on oxygen consumption. These results suggest that the effective protection of tetramethylpyrazine against ischemic brain injury might be due to its scavenging of reactive oxygen species and regulation on nitric oxide production, and consequent prevention of peroxynitrite formation. (C) 2003 Elsevier Science Inc. All rights reserved.