Lower extremity motor function and disability in mild cognitive impairment
Lower extremity motor function and disability in mild cognitive impairment
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DOI：
10.1080/03610730701319210
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发表时间：
2007-07-01
影响因子：
1.8
通讯作者：
Bennett, D. A.
中科院分区：
文献类型：
--
作者：
Boyle, P. A.;Wilson, R. S.;Bennett, D. A.
最近的研究表明，下肢运动功能障碍可能是轻度认知障碍（MCI）的一个特征，但对MCI中下肢运动功能障碍的性质和意义知之甚少。这项研究的目的是在Rush记忆和衰老项目中研究MCI与步态、平衡和力量受损的关联程度，以及MCI患者下肢功能与残疾的关系，这是一项针对老年常见慢性疾病的临床病理研究。在一系列对年龄、性别和教育程度进行调整的分析中，患有轻度认知障碍的个体比没有认知障碍的个体表现出更多的步态和平衡受损。由于血管因素可能导致下肢运动功能障碍，作者重复了最初的分析，包括血管危险因素和血管疾病的术语，MCI和下肢运动功能障碍之间的联系仍然存在。此外，在轻度认知障碍患者中，步态和平衡障碍与残疾的可能性增加有关。这些发现表明，下肢运动功能障碍是常见的，并有助于MCI致残，但MCI的下肢运动功能障碍似乎不能用本研究中检查的血管因素来解释。
Recent findings suggest that lower extremity motor dysfunction may be a feature of mild cognitive impairment (MCI), but little is known about the nature and significance of lower extremity motor dysfunction in MCI. The aim of this study was to examine the extent to which MCI is associated with impaired gait, balance, and strength and to examine the relation of lower extremity function to disability among persons with MCI in the Rush Memory and Aging Project, a clinical-pathologic study of common chronic conditions of old age. In a series of analyses adjusted for age, sex, and education, individuals with MCI exhibited more impaired gait and balance than individuals without cognitive impairment. Because vascular factors can contribute to lower extremity motor dysfunction, the authors repeated the initial analyses including terms for vascular risk factors and vascular disease, and the associations between MCI and lower extremity motor dysfunction persisted. Moreover, among those with MCI, impairments in gait and balance were associated with an increased likelihood of disability. These findings suggest that lower extremity motor dysfunction is common and contributes to disability in MCI, but lower extremity motor dysfunction in MCI does not appear to be explained by the vascular factors examined in this study.